1. Signaling Pathways
  2. Stem Cell/Wnt
    TGF-beta/Smad
  3. RUNX

RUNX (Runt 相关转录因子)

Runt-related transcription factors; RUNX

Runt-related transcription factors (RUNX) is a transcription factor that regulates the bone development, cell growth and tumor metastasis. There are three RUNX transcription factors in mammals: RUNX1, RUNX2 and RUNX3. RUNX1 is expressed in mesenchymal cells and proliferating chondrocytes, and acts as a compensatory factor for RUNX2 to promote the proliferation and differentiation of osteoblasts; RUNX1 is also expressed in hematopoietic cells and certain cancer cells. RUNX2 is expressed in bones and chondrocytes, and is a key regulator of osteoblast differentiation and chondrocyte hypertrophy. RUNX2 is also highly expressed in the nucleus and cytoplasm of prostate cancer cells, that binds to microtubules in the cytoplasm and is associated with the tumor metastasis. RUNX3 is expressed in hypertrophic chondrocytes plays an anabolic function in cartilage metabolism, and maintains the health of cartilage by regulating the expression of genes such as Acan and Prg4. Runt-related transcription factors dysfunction leads to bone diseases like osteoporosis, skeletal abnormality or osteoarthritis. In addition, runt-related transcription factors is abnormal expressed in certain cancer cells, which is supposed to be associated with tumor development[1][2].

RUNX 亚型特异性产品:

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-138617
    AI-10-47 Inhibitor 98.93%
    AI-10-47 是 CBFβ-RUNX 结合的小分子抑制剂,其 IC50 值为 3.2 μM。
    AI-10-47
  • HY-107245
    Segetalin B

    王不留行环肽 B

    Activator 99.51%
    Segetalin B 是一种具有口服活性的环五肽,发现于 Vaccaria segetalis,具有雌激素样活性。Segetalin B 促进体外卵巢切除大鼠骨髓间充质干细胞矿化,提高骨钙素、BMP-2、ALP 和 SIRT1 活性水平。Segetalin B 可显著降低去卵巢大鼠骨丢失,抑制钙磷丢失,提高 ALP 活性,上调 Runx2、Osterix、SIRT1,下调 Notch 胞内结构域 (NICD)、乙酰基 NICD、hairy and enhancer of split 1 (Hes1)。Segetalin B 有望用于绝经后骨质疏松症 (PMOP) 的研究。
    Segetalin B

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.