2. 重组蛋白
  3. Cytokines and Growth Factors
  4. EGF Superfamily

EGF Superfamily  (EGF 超家族)

表皮生长因子 (EGF) 家族是一组与表皮生长因子结构相似的生长因子。EGF是一种有效的促有丝分裂肽。EGF家族成员包括转化生长因子-α (TGF-alpha)、肝素结合EGF样生长因子 (HB-EGF)、双调蛋白、表皮调节素、β 细胞蛋白、上皮调节蛋白、epigen、神经调节素 1-6。EGF家族成员的生物学效应是由EGF受体 (EGFR/ErbB) 酪氨酸激酶家族介导的，该家族包括四个成员：EGFR (ERBB1)、ERBB2 (NEU/HER2受体)、ERBB3和ERBB4。EGF受体在结合配体后被激活，进而激活了多效应的信号级联：细胞增殖，减少凋亡以及血管生成。

Epidermal growth factor (EGF) family is a group of growth factors with similar structural to EGF which is a potent mitogenic peptide. EGF family members include transforming growth factor-α (TGF-alpha), heparin-binding EGF-like growth factor (HB-EGF), amphiregulin, betacellulin, epiregulin, epigen, neuregulins 1-6. The biological effects of the EGF family members are mediated by the EGF receptor (EGFR/ErbB) tyrosine kinase family, which consists of four members: EGFR (ERBB1), ERBB2 (NEU/HER2 receptor), ERBB3, and ERBB4. EGF receptors are activated following the binding of ligands, and then activate signaling cascades that have many effects: cell proliferation, reduced apoptosis, and angiogenesis.

 
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