1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. Aquaporin

Aquaporin (水通道蛋白)

AQP

Aquaporins (AQPs) are integral membrane proteins that facilitate the transport of water across biological membranes along an osmotic gradient. There have been 13 AQP isoforms (AQP0-AQP12) identified in humans and rodents to date. AQP0-2, 4-6 and 8 are generally considered to be exclusively water channels, whereas AQP3, 7, 9 and 10 are referred to as aquaglyceroporins, as they are also permeated by glycerol. AQPs usually adopt a tetramer conformation within the cell membrane, with each monomer consisting of a single aqueous pore that is permeable to water. The movement of water and solutes through AQP channels is a passive process that is dependent on the concentration of the transported molecule.

Aquaporin 相关产品 (4):

目录号 产品名 作用方式 纯度
  • HY-126073
    DFP00173 99.59%
    DFP00173 是一种有效的,选择性的 aquaporin-3 (AQP3) 抑制剂。DFP00173 抑制小鼠和人 AQP3,IC50 值为 ∼0.1-0.4 μM。DFP00173 对 AQP3 的选择性高于同源 AQP 亚型 AQP7 和 AQP9。
  • HY-126074
    Z433927330 98.01%
    Z433927330 是一种有效、选择性的水通道蛋白 Aquaporin-7 (AQP7) 的抑制剂,对 AQP3AQP9的抑制作用较弱,对 mAQP7,mAQP3 和 mAQP9 的 IC50 值分别为∼~0.2 µM,~0.7 µM 和 ~1.1 µM。
  • HY-115460
    AER-271
    AER-271 是 AER-270 的膦酸酯前药。AER-271 是一种 aquaporin-4 (AQP4) 抑制剂,有潜力用于急性缺血性中风的研究。
  • HY-N2057
    Steviol

    甜菊醇

    99.16%
    Steviol 是甜菊糖甙的主要代谢物。Steviol 通过降低 AQP2 的表达和促进 AQP2 的降解以减缓肾囊肿的生长。