2. 重组蛋白
  3. Enzymes & Regulators
  4. Protein Tyrosine Kinases

Protein Tyrosine Kinases  (蛋白酪氨酸激酶)

重组蛋白定制服务

酪氨酸激酶 (Tyrosine kinases) 是一类酶，它们利用 ATP 作为磷酸盐供体，催化靶蛋白中特定的酪氨酸残基的磷酸化。酪氨酸激酶主要分为受体酪氨酸激酶 (RTK，如 EGFR、PDGFR、FGFR 和 IR) 和非受体酪氨酸激酶 (NRTK，如SRC、ABL、FAK和Janus激酶)。 在人体内 90 种酪氨酸激酶中，58 种是受体型，归为20 类。 32个NRTKs可以归为 10 个类。 酪氨酸激酶是信号级联的重要介质，它在响应细胞外部和内部刺激，控制生长、分化、粘附、运动、代谢和凋亡等多种生物过程中发挥着关键作用。据报道，在人类中，酪氨酸激酶在许多疾病状态的发展中发挥着重要作用，包括糖尿病和癌症。 此外，酪氨酸激酶基因也与多种先天性综合症相关。

Tyrosine kinases are a family of enzymes, which catalyzes phosphorylation of select tyrosine residues in target proteins by using ATP as phosphate donor. Tyrosine kinases are primarily divided into receptor tyrosine kinase (RTK) such as EGFR, PDGFR, FGFR and the IR, and non-receptor tyrosine kinase (NRTK) such as SRC, ABL, FAK and Janus kinase. Of the 90 tyrosine kinases in human, 58 are receptor type, distributed into 20 classes. The 32 NRTKs can be placed in 10 classes. Tyrosine kinases are important mediators of the signaling cascade, determining key roles in diverse biological processes like growth, differentiation, adhesion, motility, metabolism and apoptosis in response to external and internal stimuli. In humans, it is reported that tyrosine kinases play significant roles in the development of many disease states, including diabetes and cancer. In addition, tyrosine kinase genes have also been linked to a wide variety of congenital syndromes.

 
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