1. 重组蛋白
  2. Receptor Proteins
  3. G-Protein-Coupled Receptors (GPCRs)

G-Protein-Coupled Receptors (GPCRs)  (G-蛋白偶联受体)

G 蛋白偶联受体 (GPCRs),也称7TM受体,是最大和最重要的一类整合膜蛋白家族的统称。它们介导细胞对大多数激素、代谢物、细胞因子和神经递质的反应,因此是药物发现的“富有成效靶点”。GPCRs 能够感知胞外信号并将其转化为异源三聚体 G蛋白,再由异源三聚体G蛋白将这些信号转导到胞内合适的下游效应体,从而在各个信号通路中发挥重要作用。 GPCRs根据序列和功能分为6类:视紫红质 (A 类)、分泌素 (B 类)、代谢性谷氨酸受体 (C类)、真菌交配信息素受体 (D类)、cAMP 受体 (E类) 和 frizzled/smoothened 受体 (F类)。根据脊椎动物中的替代分类系统 (GRAFS),GPCRs 可分为视紫红质 (A 类)、分泌素(B 类)、谷氨酸 (C 类)、粘附和Frizzled/Taste2 受体。

G Protein-Coupled Receptors (GPCRs), also called 7TM receptors, are the largest and most important integral membrane protein families, which mediate cellular responses to most hormones, metabolites, cytokines, and neurotransmitters, and therefore serve as “fruitful targets” for drug discovery. G Protein Coupled Receptors (GPCRs) perceive many extracellular signals and transduce them to heterotrimeric G proteins, which further transduce these signals intracellular to appropriate downstream effectors and thereby play an important role in various signaling pathways. GPCRs are categorized into six classes based on sequence and function: rhodopsin-like receptors (family A), secretin-like (family B), glutamate (family C), fungal mating pheromone receptors (Class D), cAMP receptors (Class E) and frizzled/smoothened (Class F). GPCRs in vertebrates are commonly divided in to rhodopsin (family A), secretin (family B), glutamate (family C), adhesion and Frizzled/Taste2, based on an alternative classification system (GRAFS).

目录号 产品名 / 同用名 种属 表达系统
  • HY-P71052
    Renin Protein, Human (HEK293, His)

    Renin; Angiotensinogenase; REN

    Human HEK293
  • HY-P75370
    CD97 Protein, Human (HEK293, hFc)

    Adhesion G protein-coupled receptor E5; CD97; ADGRE5

    Human HEK293
  • HY-P70352
    GLP1R Protein, Human (HEK293, Fc)

    rHuGlucagon-like peptide 1 receptor/GLP1R, Fc; Glucagon-like peptide 1 receptor; GLP-1 receptor; GLP-1-R

    Human HEK293
  • HY-P72674
    CXCR4 Protein, Human (HEK293, Fc)

    C-X-C chemokine receptor type 4; CXC-R4; LESTR; LAP-3; NPYRL; CD184; SDF-1 receptor

    Human HEK293
  • HY-P70210
    Frizzled-1 Protein, Mouse (HEK293, Fc)

    rMuFrizzled-1/Fz-1, Fc; Frizzled-1; Fz-1; mFz1; Fzd1; Frizzled homolog 1

    Mouse HEK293
  • HY-P70918
    FZD2 Protein, Mouse (HEK293, Fc)

    Frizzled-2; Fz-2; mFz2; Fzd2; frizzled (Drosophila) homolog 2

    Mouse HEK293
  • HY-P71081
    Renin Protein, Mouse (HEK293, His)

    Renin-1; Angiotensinogenase; Kidney renin; Ren1; Ren; Ren-1

    Mouse HEK293
  • HY-P74140
    Frizzled-4/CD344 Protein, Human (HEK293, His)

    CD344 antigen; CD344; EVR1; FEVR; Frizzled-4; Fz-4; FZD4

    Human HEK293
  • HY-P74141
    Frizzled-4/CD344 Protein, Human (HEK293, Fc)

    CD344 antigen; CD344; EVR1; FEVR; Frizzled-4; Fz-4; FZD4

    Human HEK293
  • HY-P77589
    CCR2b Protein-VLP, Human (HEK293)

    C-C CKR-2; CCR-2; CCR2; MCP-1-R; CMKBR2; CCR2

    Human HEK293
  • HY-P77590
    CCR2b Protein-VLP, Human (Biotinylated, HEK293)

    C-C CKR-2; CCR-2; CCR2; MCP-1-R; CMKBR2; CCR2

    Human HEK293
  • HY-P77958
    GPRC5D Protein-VLP, Human (HEK293)

    GPRC5D; MGC129713; MGC129714; orphan G-protein coupled receptor

    Human HEK293
  • HY-P77959
    GPRC5D Protein-VLP, Human (Biotinylated, HEK293)

    GPRC5D; MGC129713; MGC129714; orphan G-protein coupled receptor

    Human HEK293
  • HY-P72198
    FSHR Protein, Human (His)

    Follicle stimulating hormone receptor; Follicle stimulating hormone receptor isoform 1; Follicle-stimulating hormone receptor; Follitropin receptor; FSH receptor; FSH-R; Fshr; FSHR_HUMAN; FSHRO; LGR1; MGC141667; MGC141668; ODG1; ovarian dysgenesis 1

    Human E. coli
  • HY-P70915
    Frizzled-8 Protein, Human (HEK293, His)

    frizzled 8; frizzled family receptor 8; Frizzled8; Frizzled-8; FZ-8; FZD8; hFZ8

    Human HEK293
  • HY-P71730
    EDNRA Protein, Human (P.pastoris, His)

    Ednra; ET A; ET-A; ETA; ETA R; ETA-R; ETAR; ETRA; G protein coupled receptor; hET AR; hET-AR; MFDA

    Human P. pastoris
  • HY-P72138
    CHRM1 Protein, Rat (His)

    Chrm1; Chrm-1Muscarinic acetylcholine receptor M1

    Rat E. coli
  • HY-P72159
    CXCR4 Protein, Human (His-SUMO)

    C-X-C chemokine receptor type 4; CD184; CD184 antigen; Chemokine C X C motif; receptor 4; Chemokine CXC Motif Receptor 4; CXC-R4; CXCR-4; CXCR4; CXCR4_HUMAN; D2S201E; FB22; Fusin; HM89; HSY3RR; LAP 3; LAP3; LCR1; LESTR; Leukocyte derived seven transmembrane domain receptor; Leukocyte-derived seven transmembrane domain receptor; Lipopolysaccharide associated protein 3; Neuropeptide Y receptor Y3; NPY3R; NPYR; NPYRL; NPYY3; NPYY3R; Probable G protein coupled receptor lcr1 homolog; SDF 1 receptor; SDF-1 receptor; SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR; Stromal cell derived factor 1 receptor; Stromal cell-derived factor 1 receptor; WHIM; WHIMS

    Human E. coli
  • HY-P72160
    CXCR4 Protein, Human (GST)

    C-X-C chemokine receptor type 4; CD184; CD184 antigen; Chemokine C X C motif; receptor 4; Chemokine CXC Motif Receptor 4; CXC-R4; CXCR-4; CXCR4; CXCR4_HUMAN; D2S201E; FB22; Fusin; HM89; HSY3RR; LAP 3; LAP3; LCR1; LESTR; Leukocyte derived seven transmembrane domain receptor; Leukocyte-derived seven transmembrane domain receptor; Lipopolysaccharide associated protein 3; Neuropeptide Y receptor Y3; NPY3R; NPYR; NPYRL; NPYY3; NPYY3R; Probable G protein coupled receptor lcr1 homolog; SDF 1 receptor; SDF-1 receptor; SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR; Stromal cell derived factor 1 receptor; Stromal cell-derived factor 1 receptor; WHIM; WHIMS

    Human E. coli
  • HY-P72206
    GLP1R Protein, Mouse (His-SUMO)

    Glp1r; Glucagon-like peptide 1 receptor; GLP-1 receptor; GLP-1-R; GLP-1R

    Mouse E. coli
目录号 产品名 作用方式 纯度