1. Signaling Pathways
  2. Apoptosis
  3. c-Myc

c-Myc 

c-Myc is the master transcription factor for cell proliferation and is involved in numeroushematological and solidcancers.

Proto-oncogene c-Myc, encoding one of the most important transcription factors, plays a pivotal role in tumor initiation and progression. c-Myc regulates hundreds of disparate target genes that participate numerous biological effects, such as cell proliferation, apoptosis, differentiation, and stem cell self-renewal. c-Myc is one of the four factors used in reprogramming somatic cells to induce pluripotent stem (iPS) cells and is implicated in maintaining cancer stem-like cells (CSCs).

The transcription factor c-Myc is a key mediator of the Notch signaling–regulated T cell differentiation. In a well-established in vitro differentiation model of T lymphocytes from hematopoietic stem cells, Notch1 and 4 directly promotes c-Myc expression; dominant-negative (DN) c-Myc inhibits early T cell differentiation. Moreover, the c-Myc expression activated by Notch signaling increases the expression of survivin, an inhibitor of apoptosis (IAP) protein.

c-Myc gene, as a transcription factor of hTERT, is over expressed in a variety of tumors.c-Myc and hTERT expression in local recurrent gastric cancer tissues is much higher than in primary gastric cancer tissues at the protein and mRNA levels.

c-Myc 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-100669
    Mycro 3 Inhibitor 99.33%
    Mycro 3 是一种有效的选择 Myc-Max 二聚化抑制剂。Mycro 3 可用于胰腺癌的研究。
  • HY-12703
    KSI-3716 Inhibitor 98.55%
    KSI-3716 是一种有效的 c-Myc 抑制剂,可阻断 c-MYC/MAX 与靶基因启动子的结合。KSI-3716 是一种有效的膀胱内化疗剂,可用于膀胱癌的研究。
  • HY-124675
    MYCMI-6 Inhibitor
    MYCMI-6 (NSC354961) 是一种有效的选择性内源性 MYC:MAX 蛋白相互作用抑制剂。 MYCMI-6 阻断 MYC 驱动的转录。MYCMI-6 选择性结合 MYC bHLHZip 域,Kd 值为 1.6 μM。MYCMI-6 以 MYC 依赖性的方式抑制肿瘤细胞的生长 (IC50<0.5 μM)。MYCMI-6 对正常人细胞无细胞毒性。MYCMI-6 诱导细胞凋亡 (apoptosis)。
  • HY-122683
    sAJM589 Inhibitor 99.65%
    sAJM589 是一种 Myc 抑制剂,能干扰 Myc- max 异二聚体的形成,其 IC50 值为 1.8 μM。
  • HY-N6747
    Stauprimide Inhibitor ≥98.0%
    Stauprimide 是一种促进胚胎干细胞 (ESC) 分化的星形孢菌素类似物。Stauprimide 与 MYC 转录因子 NME2 结合并阻断其在 ESC 中的核定位,导致 MYC 转录的下调, 是一种非广谱抑制剂。
  • HY-121418
    Lusianthridin Inhibitor
    Lusianthridin 是来自 Dendrobium venustum 的天然化合物,具有抗迁移作用。Lusianthridin 通过抑制Src-STAT3 信号,促进c-Myc 的降解。
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