1. Signaling Pathways
  2. Apoptosis
  3. c-Myc

c-Myc

c-Myc is the master transcription factor for cell proliferation and is involved in numeroushematological and solidcancers.

Proto-oncogene c-Myc, encoding one of the most important transcription factors, plays a pivotal role in tumor initiation and progression. c-Myc regulates hundreds of disparate target genes that participate numerous biological effects, such as cell proliferation, apoptosis, differentiation, and stem cell self-renewal. c-Myc is one of the four factors used in reprogramming somatic cells to induce pluripotent stem (iPS) cells and is implicated in maintaining cancer stem-like cells (CSCs).

The transcription factor c-Myc is a key mediator of the Notch signaling–regulated T cell differentiation. In a well-established in vitro differentiation model of T lymphocytes from hematopoietic stem cells, Notch1 and 4 directly promotes c-Myc expression; dominant-negative (DN) c-Myc inhibits early T cell differentiation. Moreover, the c-Myc expression activated by Notch signaling increases the expression of survivin, an inhibitor of apoptosis (IAP) protein.

c-Myc gene, as a transcription factor of hTERT, is over expressed in a variety of tumors.c-Myc and hTERT expression in local recurrent gastric cancer tissues is much higher than in primary gastric cancer tissues at the protein and mRNA levels.

c-Myc 相关产品 (13):

Cat. No. Product Name Effect Purity
  • HY-12702
    10058-F4 Inhibitor 99.92%
    10058-F4是 c-Myc 抑制剂,其阻止c-Myc-Max二聚化和c-Myc靶基因表达的反式激活。
  • HY-16291
    APTO-253 Inhibitor
    APTO-253 是一种小分子,可抑制c-Myc表达,稳定 G-四链体 DNA 并诱导急性髓样白血病细胞的细胞周期停滞和凋亡。APTO-253 通过诱导 Kruppel-like factor 4 (KLF4) 抑癌因子介导抗癌活性。
  • HY-19735
    KJ Pyr 9 Inhibitor 99.25%
    KJ Pyr 9 是 MYC 的抑制剂。体外实验中, KJ Pyr 9 抑制 MYC 的 Kd 值为 6.5±1.0 nM。
  • HY-100669
    Mycro 3 Inhibitor 98.63%
    Mycro 3 是一种有效的选择性 c-Myc 抑制剂。
  • HY-100996
    10074-G5 Inhibitor
    10074-G5是c-Myc-Max二聚化抑制剂,IC50值为146 μM。
  • HY-129601
    MYCi975 Inhibitor
    MYCi975 (NUCC-0200975) 是一种具有口服活性的 MYC 抑制剂,它破坏 MYC/MAX 相互作用,促进 MYC T58 磷酸化和 MYC 降解,并损害 MYC 驱动的基因表达。MYCi975 (NUCC-0200975) 具有很强的抗肿瘤作用和良好的耐受性,增加肿瘤免疫细胞浸润,增强肿瘤对抗 PD1 免疫治疗的敏感性。
  • HY-122683
    sAJM589 Inhibitor
    sAJM589 是一种 Myc 抑制剂,能干扰 Myc- max 异二聚体的形成,其 IC50 值为 1.8 μM。
  • HY-129600
    MYCi361 Inhibitor
    MYCi361 (NUCC-0196361) 是一种 MYC 抑制剂,其与 MYC 结合的 Kd 为 3.2 μM。MYCi361 (NUCC-0196361) 抑制肿瘤生长并增强 anti-PD1 免疫疗法。
  • HY-103038
    ML327 Inhibitor 98.04%
    ML327 是 MYC 的阻断剂,也可以去阻遏 E-钙粘蛋白转录和逆转上皮-间质转化 (EMT)。
  • HY-119271
    CMLD010509 Inhibitor
    CMLD010509 (SDS-1-021) 是支持多发性骨髓瘤 (MM) 致癌翻译程序 (oncogenic translation program) 的高度特异性抑制剂,包括关键癌蛋白,例如 MYC,MDM2,CCND1,MAF 和 MCL-1。CMLD010509 (SDS-1-021) 对大多数 MM 细胞系的 IC50 低于 10 nM,并诱导凋亡。CMLD010509 (SDS-1-021) 是一种有效且选择性的翻译抑制剂,通过 eIF4E 磷酸化独立机制发挥作用。
  • HY-N6747
    Stauprimide Inhibitor
    Stauprimide 是一种促进胚胎干细胞 (ESC) 分化的星形孢菌素类似物。Stauprimide 与 MYC 转录因子 NME2 结合并阻断其在 ESC 中的核定位,导致 MYC 转录的下调, 是一种非广谱抑制剂。
  • HY-111411
    IZCZ-3 Inhibitor
    IZCZ-3 是有效的 c-MYC 转录抑制剂,具有抗肿瘤活性。
  • HY-12703
    KSI-3716 Inhibitor 98.55%
    KSI-3716是 c-Myc 的抑制剂。
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