1. Signaling Pathways
  2. Apoptosis
  3. FKBP


FKBP (FK506-binding protein) is one of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity. Small size FKBP family members contain only FK506-binding domain, while FKBPs with large molecular weights possess extra domains such as tetratricopeptide repeat domains, calmodulin binding and transmembrane motifs. FKBPs are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP family proteins play important functional roles in the T-cell activation, when complexed with their ligands.

FK506-binding proteins 1a and 1b (FKBP1a/1b) are immunophilin proteins that bind the immunosuppressant agent FK506 and AY 22989. FKBP12 is a ubiquitous abundant protein that acts as a receptor for FK506, binds tightly to intracellular calcium release channels and to the transforming growth factor β (TGF-β) type I receptor.

FKBP 相关产品 (11):

Cat. No. Product Name Effect Purity
  • HY-10219
    Rapamycin 99.93%
    Rapamycin (Sirolimus; AY 22989) 是一种有效且特异性的 mTOR 抑制剂,作用于 HEK293 细胞,抑制 mTORIC50 为 0.1 nM。Rapamycin 与 FKBP12 结合且抑制 mTORC1。Rapamycin 还是一种自噬 (autophagy) 激活剂。
  • HY-10218
    Everolimus 98.79%
    Everolimus (RAD001) 是有效的 mTOR 抑制剂,它与FKBP-12结合以产生免疫抑制复合物。
  • HY-13756
    Tacrolimus 98.46%
    Tacrolimus (FK506; Fujimycin) 是一种具有强效免疫抑制特性的大环内酯。 他克莫司与FK506结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶 (calcineurin phosphatase)。
  • HY-16046
    Rimiducid Activator 99.81%
    Rimiducid (AP1903) 是二聚化剂,其通过交联 FKBP 结构域起作用,启动 Fas 信号传导,引起凋亡
  • HY-13992
    AP20187 Modulator 99.80%
    AP20187 (B/B Homodimerizer) 是一种细胞渗透性分子,使 FK506 结合蛋白 (FKBP) 二聚化,启动生物信号传导级联反应和基因表达,或破坏蛋白-蛋白之间相互作用。
  • HY-13756A
    Tacrolimus monohydrate 98.46%
    Tacrolimus monohydrate (FK506 monohydrate; Fujimycin monohydrate) 结合到 FK506 结合蛋白 (FKBP) 形成复合体,复合体抑制钙调磷酸酶 (PP2B)。Tacrolimus monohydrate 是一种 mTOR 非依赖性的自噬诱导剂。
  • HY-13557
    Ascomycin Inhibitor >98.0%
    Ascomycin(Immunomycin, FR-900520, FK520)是tacrolimus (FK506)的类似物,具有很强的免疫抑制剂。
  • HY-102080
    SAFit2 Antagonist 98.59%
    SAFit2 是一个新型且有选择性的 FK506 结合蛋白 51 (FKBP51) 拮抗剂,其 Ki 值为 6 nM, 并且能增强 AKT2 和 AS160 的结合。
  • HY-102079
    SAFit1 Inhibitor
    SAFit1 是一种特异性的 FK506 结合蛋白 51 (FKBP51) 抑制剂,Ki 为 4±0.3 nM。
  • HY-114434
    AP1867 98.46%
  • HY-107452
    PROTAC FKBP12-binding moiety 1
    PROTAC FKBP12-binding moiety 1 是一种 FKBP 的合成配体 (SLF),可用于 PROTAC 合成。
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