1. Signaling Pathways
  2. Stem Cell/Wnt
  3. Hedgehog

Hedgehog

Hedgehog (Hh) is composed of N-terminal and C-terminal domains that dissociate in a self-catalyzed proteolytic cleavage reaction. The N-terminal product HhNp, modified by cholesterol during self-cleavage, harbors all known Hh signaling activities. When synthesized in the absence of the C-terminal domain (and hence lacking cholesterol modification), the N-terminal domain is aberrantly targeted and released selectively into the retina.

Hedgehog signaling pathway is linked to tumorigenesis and is aberrantly activated in a variety of cancers. Hh ligands bind to and suppress the transmembrane receptor Patched (PTCH), which suppresses Smoothened (SMO), a seven-transmembrane-helix protein that positively regulates the Hh pathway.

Sonic hedgehog (Shh) is a morphogen essential to the developing nervous system that continues to play an important role in adult life by contributing to cell proliferation and differentiation, maintaining blood-brain barrier integrity, and being cytoprotective against oxidative and excitotoxic stress, all features of importance in amyotrophic lateral sclerosis (ALS).

Indian hedgehog (Ihh), a signaling molecule that plays a pivotal role in the regulation of chondrocyte proliferation, maturation, and ossification both in long-bone development and digit joint formation, has also been found to be essential for temporomandibular joint (TMJ) development.

Desert hedgehog (Dhh), one of the Hedgehog family members, is expressed by Schwann cells of peripheral nerves.

Hedgehog 相关产品 (13):

Cat. No. Product Name Effect Purity
  • HY-10440
    Vismodegib Inhibitor 99.97%
    Vismodegib 是一种可口服的 hedgehog 抑制剂,IC50 值为 3 nM;同时可抑制 P-gp 和 ABCG2 的活性,IC50 值分别为 3.0 μM 和 1.4 μM。
  • HY-17024
    Cyclopamine Antagonist 99.97%
    Cyclopamine 是 Hedgehog 通路的拮抗剂,在细胞实验中的 IC50 为 46 nM。
  • HY-100790
    Ciliobrevin A Inhibitor 98.72%
    Ciliobrevin A 是一种 Hedgehog (Hh) 信号通路抑制剂,平均抑制浓度 (IC50) 值小于 10 μM。
  • HY-18366A
    RU-SKI 43 hydrochloride Inhibitor >98.0%
    RU-SKI 43 hydrochloride 是一种有效的选择性刺猬酰基转移酶 (Hhat) 抑制剂,IC50 为 850 nM。RU-SKI 43 hydrochloride 通过独立于平滑化的非规范信号传导降低 Gli-1 激活,并抑制 Akt 和 mTOR 通路活性。RU-SKI 43 hydrochloride 具有抗癌活性。
  • HY-13307
    JK184 Inhibitor 99.95%
    JK184 是一种有效的 Hedgehog (Hh) 抑制剂,在哺乳动物细胞中,IC50 为 30 nM。
  • HY-113965
    CUR61414 Inhibitor >99.0%
    CUR61414 是一种新型的可渗透细胞的 Hedgehog 信号通路抑制剂 (IC50 =100-200 nM),CUR61414 是氨基脯氨酸类化合物的小分子成员,可选择性结合 Smoothened (Smo)Ki  值为 44 nM。CUR-61414可以诱导癌细胞凋亡 (apoptosis) 而不会影响非癌症细胞。
  • HY-121802
    Dynarrestin Inhibitor
    Dynarrestin 是细胞质动力蛋白 1 和 2 的氨基噻唑抑制剂。Dynarrestin 快速可逆地抑制动力蛋白 1 驱动的微管在体外滑动和细胞内动力蛋白 1 和 2 依赖性过程,而不影响 ATP 水解和干扰纤毛发生。Dynarrestin 抑制神经元前体和肿瘤细胞的刺猬因子 (Hh) 依赖性增殖。
  • HY-122632
    Ciliobrevin D Inhibitor
    Ciliobrevin D 是一种细胞渗透性,可逆和特异性的 AAA + ATPase 运动细胞质动力蛋白抑制剂。Ciliobrevin D 抑制 Hedgehog (Hh) 信号和初级纤毛形成。Ciliobrevin D 在体外抑制依赖于动力蛋白的微管滑动和 ATPase 活性。
  • HY-100224
    SANT-1 Inhibitor 99.85%
    SANT-1 是一种有效的 Smo 拮抗剂,能够抑制 Hedgehog 通路,在 Shh-LIGHT2 和 SmoA1-LIGHT2 实验中,IC50 值分别为 20 nM 和 30 nM。
  • HY-100036
    MK-4101 Inhibitor 98.31%
    MK-4101 是一种 SMO 拮抗剂 (对 293 细胞的 IC50 为 1.1 µM),也是一种有效的 hedgehog 途径抑制剂 (对小鼠细胞的 IC50 为 1.5 µM;对 KYSE180 食管癌细胞的 IC50 为 1 µM)。MK-4101 具有强大的抗肿瘤活性,能抑制肿瘤细胞增殖并诱导细胞凋亡。
  • HY-N0836
    Jervine Inhibitor 99.03%
    Jervine (11-Ketocyclopamine)是一种有效的刺猬 (Hh) 抑制剂,IC50 为 500-700 nM。Jervine 是来自 Veratrum album 的根茎的天然致畸性甾体生物碱。Jervine 具有抗炎和抗氧化特性。
  • HY-18366
    RU-SKI 43 Inhibitor
    RU-SKI 43 是一种有效的选择性刺猬酰基转移酶 (Hhat) 抑制剂,IC50 为 850 nM。RU-SKI 43 通过独立于平滑化的非规范信号传导降低 Gli-1 激活,并抑制 Akt 和 mTOR 通路活性。RU-SKI 43 具有抗癌活性。
  • HY-108439
    Neurodazine Activator >99.0%
    Neurodazine 是一种咪唑类小分子,是多能干细胞神经发生的促进剂,通过激活 WntShh 信号通路促进神经发生。Neurodazine 选择性抑制 P19 细胞的星形胶质细胞分化。
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