1. Signaling Pathways
  2. Apoptosis
  3. Survivin


Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. This has been shown by disruption of survivin induction pathways leading to increase in apoptosis and decrease in tumour growth. Survivin expression is highly regulated by the cell cycle and is only expressed in the G2-M phase. Survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis. Survivin is highly expressed in most cancers and associated with chemotherapy resistance, increased tumor recurrence, and shorter patient survival, making antisurvivin therapy an attractive cancer treatment strategy.

Survivin 相关产品 (7):

目录号 产品名 作用方式 纯度
  • HY-10194
    Sepantronium bromide Inhibitor ≥98.0%
    Sepantronium bromide (YM-155) 是一种 survivin 抑制剂,其 IC50 为 0.54 nM。
  • HY-136538
    LQZ-7I Inhibitor 99.81%
    LQZ-7I 是一种靶向 survivin 的抑制剂。LQZ-7I 抑制生存素二聚化。LQZ-7I 口服有效抑制异种移植肿瘤生长并诱导肿瘤中生存素的损失。
  • HY-U00177
    GDP366 Inhibitor 99.73%
    GDP366 是 survivinOp18 的双重抑制剂,抑制癌细胞生长,诱导细胞衰老和有丝分裂突变。
  • HY-N3001
    Isolinderalactone Inhibitor
    Isolinderalactone 通过抑制内皮细胞 VEGFR2 活化,抑制人胶质母细胞瘤的生长和血管生成活性。Isolinderalactone 抑制Bcl-2survivinXIAP的表达,增加 cleaved caspase-3 的水平。
  • HY-N1988
    Cucurbitacin IIa

    葫芦素 IIa; 雪胆素甲

    Inhibitor 99.27%
    Cucurbitacin IIa 是从园果雪胆中分离得到的三萜烯,可诱导癌细胞凋亡。Cucurbitacin IIa 可降低癌细胞中生存素 survivin 的表达,降低磷酸化组蛋白 H3 的水平,增加裂解的 PARP 的水平。
  • HY-10194A
    Sepantronium hydrochloride Inhibitor
    Sepantronium hydrochloride (YM-155 hydrochloride) 是一种新型 survivin 抑制剂,对 survivin 启动子的 IC50 为 0.54 nM。
  • HY-P1750
    Shepherdin (79-87) Antagonist
    Shepherdin (79-87) 是 Shepherdin 的 79 至 87 氨基酸片段。Shepherdin 是一种 Hsp90-Survivin 复合物的拟肽拮抗剂。具有抗肿瘤活性。
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