1. Signaling Pathways
  2. Metabolic Enzyme/Protease
    Neuronal Signaling
  3. COMT

COMT

Catechol O-methyltransferase (COMT) is a ubiquitous bisubstrate magnesium-dependent enzyme found in plants, animals and microorganisms. COMT catalyses the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to one of the hydroxyl oxygen atoms (preferentially the 3-hydroxyl) in a catechol substrate. Physiological substrates of COMT are catecholamine neurotransmitters such as dopamine, noradrenaline, adrenaline and their metabolites. COMT also methylates catecholic steroids such as 2-hydroxyestradiol as well as a range of other catecholic compounds including neuroactive drugs such as L-dopa, α-methyldopa and isoproterenol. COMT inhibition is a means of treating Parkinson’s disease, schizophrenia and depression. There are two isoforms of human COMT: soluble cytoplasmic COMT (S-COMT), which is mainly intracellular, and a membrane-bound form (MB-COMT), which has a single-span helix contained within a 50 amino acid extension at the N-terminus.

COMT is an enzyme that plays a major role in catechol neurotransmitter deactivation. Inhibition of COMT can increase neurotransmitter levels, which provides a means of treatment for Parkinson’s disease, schizophrenia and depression.

COMT 相关产品 (11):

Cat. No. Product Name Effect Purity
  • HY-B1473
    Serotonin hydrochloride Inhibitor 99.97%
    Serotonin hydrochloride 是 CNS 中的单胺神经递质和内源性 5-HT 受体激动剂。Serotonin hydrochloride 也是儿茶酚 O-甲基转移酶 (COMT) 的抑制剂其 Ki 值为 44 μM。
  • HY-14280
    Entacapone Inhibitor 99.97%
    Entacapone是特异的外周活性的邻苯二酚-O-甲基转移酶(COMT)抑制剂,IC50为151 nM。
  • HY-N0529
    Rosmarinic acid Inhibitor 99.29%
    Rosmarinic acid 是植物中广泛存在的一种酚酯化合物。Rosmarinic acid 抑制 MAO-AMAO-BCOMTIC50 分别为 50.1,184.6 和 26.7 μM。
  • HY-17406
    Tolcapone Inhibitor 99.74%
    Tolcapone (Ro 40-7592) 是一种选择性,有效和口服的外周和中枢 COMT 抑制剂。Tolcapone 还是一种 α-synAβ42 寡聚和原纤维形成的有效抑制剂,可防止 PC12 细胞中这两种蛋白质聚集引起的细胞外毒性。
  • HY-14896
    Opicapone Inhibitor 99.60%
    Opicapone 是一种有效的第三代儿茶酚-O-甲基转移酶 (COMT)抑制剂,有潜力用于帕金森病和运动波动的研究。Opicapone 降低细胞 ATP 含量,IC50 为 98 μM。
  • HY-100642S
    3-O-Methyltolcapone D7 Inhibitor
    3-O-Methyltolcapone D7 (Ro 40-7591 D7) 是 3-O-Methyltolcapone 的氘代物。3-O-Methyltolcapone 是 Tolcapone 的代谢产物。Tolcapone 是一种口服活性,可逆,选择性和有效的 COMT 抑制剂。Tolcapone 可穿过血脑屏障,可用于治疗帕金森氏病。
  • HY-100642
    3-O-Methyltolcapone Inhibitor
    3-O-Methyltolcapone (Ro 40-7591) 是 Tolcapone 的代谢产物。Tolcapone 是一种口服活性,可逆,选择性和有效的 COMT 抑制剂。Tolcapone 可穿过血脑屏障,可用于治疗帕金森氏病。
  • HY-17406S
    Tolcapone D7 Inhibitor
    Tolcapone D7 (Ro 40-7592 D7) 是 Tolcapone 的氘代物。Tolcapone 是一种选择性,有效和口服的 COMT 抑制剂。Tolcapone 还是一种 α-synAβ42 寡聚和原纤维形成的有效抑制剂,可防止 PC12 细胞中这两种蛋白质聚集引起的细胞外毒性。
  • HY-100562
    Flopropione Inhibitor 98.37%
    Flopropione 是 5-HT 受体拮抗剂,也是儿茶酚-O-甲基转移酶 (COMT) 的抑制剂。Flopropione 也可作为解痉剂。
  • HY-106405
    Nebicapone Inhibitor
    Nebicapone (BIA 3-202) 是一种可逆的儿茶酚-O-甲基转移酶 (COMT) 抑制剂,主要通过葡萄糖醛酸化代谢。Nebicapone 主要是外周作用的抑制剂,通过抑制 COMT 降低 L-DOPA 向 3-O-甲基-DOPA 的生物转化,Nebicapone 具有治疗帕金森病的潜力。
  • HY-14280A
    Entacapone sodium salt Inhibitor
    Entacapone是特异的儿茶酚-o-甲基转移酶(COMT)抑制剂,IC50为151 nM。
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