2. 重组蛋白
  3. Cytokines and Growth Factors
  4. HGF & Receptors

HGF & Receptors  (肝细胞生长因子及受体)

肝细胞生长因子 (HGF) 是一类具有血管生成能力的因子。它属于可溶性细胞因子家族，也是纤溶酶原相关生长因子家族的成员。HGF由间充质干细胞分泌，通过其受体c-Met调控上皮细胞、内皮细胞和造血干细胞的细胞的生长、运动和形态发生。正常条件下，HGF/c-Met轴在机体正常生物学功能中起重要作用。而在癌细胞中，异常激活的HGF/c-Met轴的通过刺激PI3K/AKT、Ras/MAPK、JAK/STAT、SRC、Wnt/β-catenin等信号通路促进肿瘤的发生和发展。

Hepatocyte growth factor (HGF, also known as Scatter Factor) is among a group of factors possessing angiogenic ability. It belongs to the soluble cytokine family and is also a member of the plasminogen-related growth factor family. HGF is secreted by mesenchymal stem cells，and regulates cell growth, cell motility and morphogenesis of epithelial cells, endothelial cells, and haematopoietic stem cells, through its receptor, c-Met. Under normal conditions, HGF/c-Met axis plays an important role in normal biological functions in organism. However, in cancer cells, abnormal activation of HGF/c-Met axis promotes tumor development and progression by stimulating the PI3K/AKT, Ras/MAPK, JAK/STAT, SRC, Wnt/β-catenin, and other signaling pathways.

 
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