1. Signaling Pathways
  2. Apoptosis
  3. PKD

PKD (蛋白激酶D)

Protein kinase D

PKD (Protein kinase D) is an evolutionarily conserved protein kinase family with structural, enzymological, and regulatory properties different from the PKC family members. Signaling through PKD is induced by a remarkable number of stimuli, including G-protein-coupled receptor agonists and polypeptide growth factors. PKD family of serine/threonine protein kinases has three members: PKD1, PKD2, PKD3. PKD1, the most studied member of the family, is increasingly implicated in the regulation of a complex array of fundamental biological processes, including signal transduction, cell proliferation and differentiation, membrane trafficking, secretion, immune regulation, cardiac hypertrophy and contraction, angiogenesis, and cancer. PKD mediates such a diverse array of normal and abnormal biological functions via dynamic changes in its spatial and temporal localization, combined with its distinct substrate specificity.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-107202
    Polyinosinic-polycytidylic acid 99.40%
    Polyinosinic-polycytidylic acid sodium (Poly(I:C)) 是双链 RNA 的合成类似物,是一种 TLR3 和视黄酸诱导型基因 I 受体 (RIG-IMDA5) 的激动剂。Polyinosinic-polycytidylic acid 可以用作疫苗佐剂,以增强先天性和适应性免疫反应,并改变肿瘤的微环境,还可以直接触发癌细胞发生凋亡 (apoptosis)。
    Polyinosinic-polycytidylic acid
  • HY-15698A
    CRT0066101 dihydrochloride Inhibitor 99.92%
    CRT0066101 dihydrochloride 是一种有效的具有口服活性的 PKD 抑制剂,对 PKD1PKD2PKD3IC50 值分别为 1 nM、2.5 nM 和 2 nM。CRT0066101 dihydrochloride 也是一种有效的 PIM2 抑制剂,IC50 约为 135.7nM。CRT0066101 dihydrochloride 具有抗癌作用。
    CRT0066101 dihydrochloride
  • HY-13941
    1-Naphthyl PP1 Inhibitor 99.08%
    1-Naphthyl PP1 (1-NA-PP 1) 是一种选择性的 src 家族激酶和蛋白激酶 D 抑制剂。1-Naphthyl PP1 抑制 v-Src 和 c-Fyn,c-Abl,CDK2 和CAMK II,IC50 分别为 1.0,0.6,0.6,18 和 22 μM。
    1-Naphthyl PP1
  • HY-12239
    CID755673 Inhibitor 99.12%
    CID755673是高效选择性的PKD1抑制剂,IC50 of 值为182 nM。
  • HY-13454
    CID 2011756 Inhibitor
    CID 2011756 是一种广谱的,ATP 竞争性的 PKD 抑制剂,对 PKD1IC50 值为 3.2 µM,在细胞中对 PKD2PKD3IC50 值分别为 0.6 和 0.7 µM;CID 2011756 同时具有抗肿瘤活性。
    CID 2011756
  • HY-15698
    CRT0066101 Inhibitor
    CRT0066101 是一种有效的具有口服活性的 PKD 抑制剂,对 PKD1PKD2PKD3IC50 值分别为 1 nM、2.5 nM 和 2 nM。CRT0066101 也是一种有效的 PIM2 抑制剂,IC50 约为 135.7nM。CRT0066101 具有抗癌作用。
  • HY-15528
    kb NB 142-70 Inhibitor 98.08%
    kb NB 142-70 是一种有效的 PKD 抑制剂,对 PKD1PKD2PKD3IC50 值分别为 28.3 nM,58.7 nM 和 53.2 nM;kb NB 142-70 同时具有抗肿瘤活性。
    kb NB 142-70
  • HY-151374
    3-IN-PP1 Inhibitor
    3-IN-PP1 是一种蛋白激酶 D (PKD) 抑制剂。 3-IN-PP1 对 PKD1、PKD2 和 PKD3 具有有效广泛的 PKD 抑制活性, IC50 值分别为 108、94 和 108 nM。3-IN-PP1 也是一种广谱抗癌剂,对多种肿瘤细胞的生长有抑制作用。3-IN-PP1 可用于癌症研究。
  • HY-118052
    BPKDi Inhibitor ≥99.0%
    BPKDi 是一种有效的联吡啶 PKD 抑制剂,对 PKD1、PKD2 和 PKD3IC50 分别为 1 nM、9 nM 和 1 nM。BPKDi 阻断心肌细胞中 IIa 类 HDAC 的信号依赖性磷酸化和核输出。
  • HY-151372
    Protein kinase D inhibitor 1 Inhibitor
    Protein kinase D inhibitor 1 (compound 17m) 是一种有效的泛 PKD 抑制剂,IC50 为 17~35 nM。Protein kinase D inhibitor 1 可抑制 PKD 依赖性的皮质激素磷酸化。
    Protein kinase D inhibitor 1
  • HY-131962
    PKD-IN-1 Inhibitor
    PKD-IN-1 (化合物 32) 是一种氨基乙胺芳基 (AEAA) 化合物,可作为 PKD-1 抑制剂。PKD-IN-1 可用于蛋白激酶 D (PKD) 介导的疾病研究。
  • HY-112547
    CRT5 Inhibitor
    CRT5 是一种吡嗪苯甲酰胺,对经 VEGF 处理的内皮细胞中的所有三种 PKD 亚型 (对 PKD1、PKD2 和 PKD3IC50s 分别为 1、2 和 1.5 nM) 都是一种有效的选择性抑制剂。CRT5 减少 VEGF 诱导的内皮细胞迁移、增殖和微管生成。

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