1. Signaling Pathways
  2. Apoptosis
  3. PKD

PKD (蛋白激酶D)

PKD (Protein kinase D) is an evolutionarily conserved protein kinase family with structural, enzymological, and regulatory properties different from the PKC family members. Signaling through PKD is induced by a remarkable number of stimuli, including G-protein-coupled receptor agonists and polypeptide growth factors. PKD family of serine/threonine protein kinases has three members: PKD1, PKD2, PKD3. PKD1, the most studied member of the family, is increasingly implicated in the regulation of a complex array of fundamental biological processes, including signal transduction, cell proliferation and differentiation, membrane trafficking, secretion, immune regulation, cardiac hypertrophy and contraction, angiogenesis, and cancer. PKD mediates such a diverse array of normal and abnormal biological functions via dynamic changes in its spatial and temporal localization, combined with its distinct substrate specificity.

PKD 亚型特异性产品:

  • PKD1

  • PKD2

  • PKD3

PKD 相关产品 (5):

目录号 产品名 作用方式 纯度
  • HY-15698A
    CRT0066101 dihydrochloride Inhibitor 99.53%
    CRT0066101 dihydrochloride是有效,选择性的 PKD 抑制剂,对PKD1,2和3的IC50值分别为1,2.5和2 nM。
  • HY-12239
    CID755673 Inhibitor 99.12%
    CID755673是高效选择性的PKD1抑制剂,IC50 of 值为182 nM。
  • HY-15528
    kb NB 142-70 Inhibitor 98.85%
    kb NB 142-70 是一种有效的 PKD 抑制剂,对 PKD1,PKD2 和 PKD3 的 IC50 值分别为 28.3 nM,58.7 nM 和 53.2 nM;kb NB 142-70 同时具有抗肿瘤活性。
  • HY-13454
    CID 2011756 Inhibitor
    CID 2011756 是一种广谱的,ATP 竞争性的 PKD 抑制剂,对 PKD1 的 IC50 值为 3.2 µM,在细胞中对 PKD2 和 PKD3 的 IC50 值分别为 0.6 和 0.7 µM;CID 2011756 同时具有抗肿瘤活性。
  • HY-112547
    CRT5 Inhibitor
    CRT5 是一种吡嗪苯甲酰胺,对经 VEGF 处理的内皮细胞中的所有三种 PKD 亚型 (对 PKD1、PKD2 和 PKD3 的 IC50s 分别为 1、2 和 1.5 nM) 都是一种有效的选择性抑制剂。CRT5 减少 VEGF 诱导的内皮细胞迁移、增殖和微管生成。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.