1. Signaling Pathways
  2. Immunology/Inflammation
  3. CD38

CD38 

CD38 is a glycoprotein found on the surface of many immune cells, including T cells, B cells and natural killer cells. Additionally, CD38 has been shown to be a bifunctional enzyme expressing both ADP-ribosyl cyclase and cADPR hydrolase activities. The role of CD38 in immune cells ranges from modulating cell differentiation to effector functions during inflammation, where CD38 may regulate cell recruitment, cytokine release, and NAD availability. In line with a role in inflammation, CD38 appears to also play a critical role in inflammatory processes during autoimmunity. Because of CD38 expression is highly upregulated on human plasma cells and especially on multiple myeloma cells.Targeting of CD38 is one of the most important and promising treatment avenues to help patients suffering from multiple myeloma.

CD38 相关产品 (1):

目录号 产品名 作用方式 纯度
  • HY-150508
    MK-0159 Inhibitor
    MK-0159 (compound 37) 是一种口服有效的和选择性的 CD38 抑制剂,对人、小鼠和大鼠 CD38 的 IC50 分别为 22、3 和 70 nM。MK-0159 对人和啮齿动物的肝脏微粒体也显示出良好的稳定性。MK-0159 增加全血和心脏的 NAD+(烟酰胺腺嘌呤二核苷酸),降低ADPR(二磷酸腺苷核糖)。
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