1. 重组蛋白
  2. Enzymes & Regulators
  3. Caspase

Caspase  (半胱天冬酶蛋白)

目录号 产品名 / 同用名 种属 表达系统
  • HY-P72874
    Caspase-3/CASP3 Protein, Human (His)

    Caspase-3; CASP-3; CPP-32; SCA-1; YAMA

    Human E. coli
  • HY-P74347
    Caspase-7/CASP7 Protein, Human (His)

    CMH-1; CASP-7; Caspase-7; MCH3; ICE-LAP3

    Human E. coli
  • HY-P71708
    Caspase-8/CASP8 Protein, Human (His)

    ALPS2B; CASP-8; ICE-like apoptotic protease 5

    Human E. coli
  • HY-P72117
    Caspase-1/CASP1 Protein, Human (GST)

    CASP-1; CASP1; CASP1_HUMAN; Caspase 1; Caspase-1 subunit p10; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1 beta converting enzyme; IL1B convertase; Interleukin 1 beta convertase; Interleukin 1B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45

    Human E. coli
  • HY-P7742
    Caspase-10/CASP10 Protein, Human (His)

    rHuCaspase-10, His; Caspase-10; CASP-10; Apoptotic Protease Mch-4; ICE-Like Apoptotic Protease 4; CASP10; MCH4

    Human E. coli
    Caspase-10 Protein, Human (His)是一个约 33.0 kDa 的 Caspase-10 蛋白,带有 His-flag,在 E. coli 中表达。Caspase -10 属于 caspase 家族,参与细胞凋亡执行期。
  • HY-P7743
    Caspase-14/CASP14 Protein, Human (His)

    rHuCaspase-14, His; Caspase-14; CASP-14; CASP14

    Human E. coli
    Caspase-14 Protein, Human (His)是一个大约 31.0 kDa 的 Caspase-14 蛋白,带有 His-flag。Caspase-14 是一种看似非凋亡的 caspase,参与角质形成细胞分化和角化。
目录号 产品名 作用方式 纯度

Upon binding to their cognate ligand, death receptors such as Fas and TRAILR can activate initiator Caspases (Pro-caspase 8 and Pro-caspase 10) through dimerization mediated by adaptor proteins such as FADD and TRADD. Active Caspase 8 and Caspase 10 then cleave and activate the effector Caspase 3, 6 and 7, leading to apoptosis. ROS/DNA damage and ER stress trigger Caspase 2 activation. Active Caspase 2 cleaves and activates Caspase 3 and initiates apoptosis directly. Caspase 2, 8 and 10 can also cleave Bid, stimulate mitochondrial outer membrane permeabilization (MOMP) and initiate the intrinsic apoptotic pathway. Following MOMP, mitochondrial intermembrane space proteins such as Smac and Cytochrome C are released into the cytosol. Cytochrome C interacts with Apaf-1, triggering apoptosome assembly, which activates Caspase 9. Active Caspase 9, in turn, activates Caspase 3, 6 and 7, leading to apoptosis. Mitochondrial release of Smac facilitates apoptosis by blocking the inhibitor of apoptosis (IAP) proteins. 

 

Following the binding of TNF to TNFR1, TNFR1 binds to TRADD, which recruits RIPK1, TRAF2/5 and cIAP1/2 to form TNFR1 signaling complex I. Formation of the complex IIa and complex IIb is initiated either by RIPK1 deubiquitylation mediated by CYLD or by RIPK1 non-ubiquitylation due to depletion of cIAPs. The Pro-caspase 8 homodimer in complex IIa and complex IIb generates active Caspase 8. This active Caspase 8 in the cytosol then carries out cleavage reactions to activate downstream executioner caspases and thus induce classical apoptosis[1][2]

 

Reference:

[1]. Thomas C, et al. Caspases in retinal ganglion cell death and axon regeneration. Cell Death Discovery volume 3, Article number: 17032 (2017).
[2]. Brenner D, et al. Regulation of tumour necrosis factor signalling: live or let die. Nat Rev Immunol. 2015 Jun;15(6):362-74.