1. 重组蛋白
  2. Cytokines and Growth Factors CAR-T related Proteins Receptor Proteins Enzymes & Regulators
  3. EGF Superfamily Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. EGFR/ErbB family
  5. EGFR

EGFR  (表皮生长因子受体 1)

表皮生长因子受体 (EGFR; ErbB1) 是表皮生长因子RTK (受体酪氨酸激酶) 家族的成员,该家族成员还包括 HER2/neu (ErbB2)、ErbB3 (HER3) 和ErbB4 (HER4)。EGFR 存在于细胞表面,并具有由细胞外配体结合外结构域、单链跨膜结构域和细胞内酪氨酸激酶结构域组成。多种配体能结合并激活EGFR,包括表皮生长因子 (EGF)、转化生长因子 (TGF-α)、双调蛋白、肝素结合EGF样生长因子和β细胞蛋白。 配体结合后,受体形成同源或异源二聚体复合物激活酪氨酸激酶结构域。EGFR的二聚体化和自磷酸化导致一系列细胞内信号事件,涉及Ras-Raf-MAPK、PI-3K/Akt、PKC 和 Stat/Jak 通路的激活。EGFR 的活化参与调控细胞增殖、分化和存活。由于其在促进细胞增殖和防止细胞凋亡方面的作用,EGFR 也被认为是一种原癌基因。

The epidermal growth factor receptor (EGFR; ErbB1) is a member of the epidermal growth factor RTK (receptor tyrosine kinases) family, which also includes HER2/neu (ErbB2), ErbB3 (HER3), and ErbB4 (HER4). The EGFR is present at the cell surface and composed of an extracellular ligand-binding ectodomain, a single chain transmembrane domain, and an intracellular tyrosine kinase domain. Multiple ligands bind to and activate the EGFR, including epidermal growth factor (EGF), transforming growth factor (TGF-α), amphiregulin, heparin-binding EGF, and betacellulin.
After ligand binding, the receptors form homo- or heterodimeric complexes activating the tyrosine kinase domain. The dimerization and autophosphorylation of EGFR result in a series of intracellular signaling events that involve activation of the Ras-Raf-MAP kinase, PI-3K/Akt, PKC, and Stat/Jak pathways. Activation of the EGFR is involved in regulating cellular proliferation, differentiation, and survival. Driven largely by its role in promoting cell proliferation and opposing apoptosis, the EGFR has been vilified as a proto-oncogene.

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