1. 重组蛋白
  2. Complement System

Complement System  (补体系统)

补体系统是先天免疫的主要成分之一,由可溶性血浆蛋白、膜型调节蛋白和受体组成。补体系统存在于血浆、组织、细胞表面,甚至细胞内。补体系统主要有三条激活途径:经典途径 (CP)、凝集素途径 (LP)、旁路途径 (AP)。这些途径依赖不同的起始分子激活,但最后殊途同归,产生相同的终端效应分子:过敏性毒素 (C4a/C3a/C5a)、膜攻击复合物 (MAC) 和调理素 (如C3b)。补体系统在防御病原体和维持宿主稳态中起着关键作用。

Complement system, a major part of the innate immunity, is a cascade of soluble plasma proteins and membrane expressed receptors and regulators. Complement system operates in plasma, in tissues, on cell surface, and even within the cell. Complement system plays a key role in host homeostasis, inflammation, and in the defense against pathogens. Complement system can be activated through three main pathways: the classical pathway (CP), the lectin pathway (LP), and the alternative pathway (AP). These pathways depend on different molecules for their initiation, but they converge to generate the same set of terminal effector molecules: anaphylatoxins (C4a/C3a/C5a), the membrane attack complex (MAC), and opsonins (e.g., C3b). Complement system plays a key role in defense against pathogens and in host homeostasis.

目录号 产品名 / 同用名 种属 表达系统
目录号 产品名 作用方式 纯度