1. Signaling Pathways
  2. Stem Cell/Wnt
  3. Gli

Gli

Gli proteins are the effectors of Hedgehog (Hh) signaling and have been shown to be involved in cell fate determination, proliferation and patterning in many cell types and most organs during embryo development. The Gli transcription factors activate/inhibit transcription by binding to Gli responsive genes and by interacting with the transcription complex. The Gli transcription factors have DNA binding zinc finger domains which bind to consensus sequences on their target genes to initiate or suppress transcription. Research showed that mutating the Gli zinc finger domain inhibited the proteins effect proving its role as a transcription factor. Gli proteins have an 18-amino acid region highly similar to the α-helical herpes simplex viral protein 16 activation domain.

Gli 相关产品 (4):

Cat. No. Product Name Effect Purity
  • HY-13901
    GANT 61 Inhibitor 99.87%
    GANT 61 是靶向Hedgehog/GLi通路的 Gli1Gli2 抑制剂。
  • HY-13282
    GANT 58 Antagonist 99.91%
    GANT 58 是一种有效的 Gli 拮抗剂,抑制 GLI1 诱导的转录,IC50 为 5 μM。
  • HY-15412
    HhAntag Inhibitor 99.26%
    HhAntag是GLI1介导的转录抑制剂,具有抗肿瘤活性。
  • HY-122590
    Glabrescione B Inhibitor
    Glabrescione B 是第一个结合 Hedgehog (Hh) 调节剂 Gli1 并通过干扰 Gli1-DNA 相互作用而削弱其活性的化合物。Glabrescione B 抑制 Hedgehog 依赖性肿瘤细胞的生长,抑制肿瘤源性干细胞的自我更新能力和克隆能力。
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