1. Signaling Pathways
  2. Stem Cell/Wnt
  3. Gli

Gli (Gli蛋白)

Gli proteins are the effectors of Hedgehog (Hh) signaling and have been shown to be involved in cell fate determination, proliferation and patterning in many cell types and most organs during embryo development. The Gli transcription factors activate/inhibit transcription by binding to Gli responsive genes and by interacting with the transcription complex. The Gli transcription factors have DNA binding zinc finger domains which bind to consensus sequences on their target genes to initiate or suppress transcription. Research showed that mutating the Gli zinc finger domain inhibited the proteins effect proving its role as a transcription factor. Gli proteins have an 18-amino acid region highly similar to the α-helical herpes simplex viral protein 16 activation domain.

Gli 相关产品 (3):

目录号 产品名 作用方式 纯度
  • HY-13901
    GANT 61 Inhibitor ≥98.0%
    GANT 61 是靶向Hedgehog/GLi通路的 Gli1Gli2 抑制剂。
  • HY-13282
    GANT 58 Antagonist 99.91%
    GANT 58 (NSC 75503) 是一种有效的 GLI 拮抗剂,抑制 GLI1 诱导的转录,IC50 为 5 μM。
  • HY-122590
    Glabrescione B Inhibitor 98.04%
    Glabrescione B 是第一个结合 Hedgehog (Hh) 调节剂 Gli1 并通过干扰 Gli1-DNA 相互作用而削弱其活性的化合物。Glabrescione B 抑制 Hedgehog 依赖性肿瘤细胞的生长,抑制肿瘤源性干细胞的自我更新能力和克隆能力。
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