1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. Ack1

Ack1 (活化的Cdc42结合蛋白激酶1)

Activated Cdc42 kinase 1; TNK2

Ack1 (Activated Cdc42 kinase 1) is an enzyme that in humans is encoded by the TNK2 gene. Ack1 binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). Ack1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. Ack1 is a survival kinase and shown to be associated with tumor cell survival, proliferation, hormone-resistance and radiation resistance. Ack1 has emerged as a new cancer target and multiple small molecule inhibitors have been reported.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15290
    AIM-100 Inhibitor 99.95%
    AIM-100 是一种有效的选择性 Ack1 抑制剂,IC50 为 21.58 nM。AIM-100 还抑制 Tyr267 磷酸化,但不抑制其他激酶,包括 PI3KAKT 亚家族成员。AIM-100 具有抗癌作用。
  • HY-10943
    GNF-7 Inhibitor 98.93%
    GNF-7 是一种多重激酶抑制剂。GNF-7 是 Bcr-Abl 的抑制剂,对 Bcr-AblWTBcr-AblT315I 作用的 IC50 值分别为 133 nM 和 61 nM。GNF-7 对 ACK1GCK 也具有抑制活性,IC50 分别为 25 nM 和 8 nM。GNF-7 可用于血液恶性肿瘤的研究。
  • HY-12331
    KRCA-0008 Inhibitor 98.88%
    KRCA-0008 是选择性的 ALK/Ack1 抑制剂,对 ALK 和 Ack1IC50 值分别为 12 和 4 nM。KRCA-0008 可用于癌症的研究。
  • HY-149989
    Ack1 inhibitor 1 Inhibitor
    Ack1 inhibitor 1 是一种有效的,选择性的,具有口服活性的ACK1激酶抑制剂,其 IC50 值为 2.1 nM。Ack1 inhibitor 1 抑制 ACK1 的磷酸化和下游 AKT 的激活。Ack1 inhibitor 1 具有抗肿瘤活性。
    Ack1 inhibitor 1
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