1. Signaling Pathways
  2. PI3K/Akt/mTOR
  3. PI4K

PI4K (磷脂酰肌醇4激酶)

The phosphatidylinositol 4-kinases (PI4Ks) synthesize phosphatidylinositol 4-phosphate (PI4P), a key member of the phosphoinositide family. PI4P defines the membranes of Golgi and trans-Golgi network (TGN) and regulates trafficking to and from the Golgi.

In mammals there are four different PI4K enzymes, two type II enzymes (PI4KIIα and PI4KIIβ) and two type III enzymes (PI4KIIIα and PI4KIIIβ). PI4KIIIβ plays key roles in mediating lipid transport, cytokinesis, maintaining lysosomal identity, and in tandem with Rab GTPases plays key roles in regulating membrane trafficking. PI4KIIIβ is critical for mediating viral replication of a number of RNA viruses through the generation of PI4P enriched viral replication platforms. Small molecule inhibitors of PI4KIIIβ are potent anti-viral agents. Development of PI4KIIIβ as an effective drug target for anti-viral therapeutics requires the generation of highly potent and specific inhibitors.

PI4K Isoform Specific Products:

  • PI4KIIIβ

  • PI4KIIIα

  • PI4K

PI4K 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-100198
    PI4KIIIbeta-IN-10 Inhibitor 99.84%
    PI4KIIIbeta-IN-10 是一种有效的 PI4KIIIβ 抑制剂,IC50 为 3.6 nM。
  • HY-U00426
    BF738735 Inhibitor 99.10%
    BF738735 是一种磷脂酰肌醇 4-激酶 IIIβ (PI4KIIIβ) 抑制剂,IC50 为 5.7 nM。
  • HY-103489
    PI-273 Inhibitor ≥98.0%
    PI-273 是第一种可逆的和特异性磷脂酰肌醇 4-激酶 (PI4KIIα) 抑制剂,IC50 为 0.47 μM。PI-273 可以抑制乳腺癌细胞的增殖,阻断细胞周期并诱导细胞凋亡
  • HY-12912
    KDU691 Inhibitor 99.56%
    KDU691 是一种咪唑吡嗪类药物,对血阶段的裂殖体、配子体和肝期具有较强的抗寄生虫活性,KDU691 是一种 Plasmodium PI4K 抑制剂。KDU691 选择性抑制双氢青蒿素预处理的恶性疟原虫。
  • HY-108313
    T-00127_HEV1 Inhibitor ≥98.0%
    T-00127_HEV1 是一个 phosphatidylinositol 4-kinase III beta (PI4KB) 抑制剂,其 IC50 值为 60 nM。
  • HY-18748
    BQR-695 Inhibitor 99.87%
    BQR-695 是一种 PI4KIIIβ 抑制剂,对于人类和疟原虫 PI4KIIIβ 的 IC50 值分别为 80 和 3.5 nM。
Isoform Specific Products

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