1. Signaling Pathways
  2. GPCR/G Protein
    Immunology/Inflammation
  3. CXCR

CXCR (CXC趋化因子受体)

CXCRs (CXC chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CXC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins, since they span thecell membrane seven times. There are currently seven known CXC chemokine receptors in mammals, named CXCR1 through CXCR7. CXCR1 and CXCR2 are closely related receptors that recognize CXC chemokines that possess an E-L-R amino acid motif immediately adjacent to their CXC motif. CXCR3 is expressed predominantly on T lymphocytes. CXCR4 is the receptor for a chemokine known as CXCL12 (or SDF-1) and, as with CCR5, is utilized by HIV-1 to gain entry into target cells. The chemokine receptor CXCR5 is selectively expressed on B cells and is involved in lymphocyte homing and the development of normal lymphoid tissue. CXCR6 was formerly called three different names (STRL33, BONZO, and TYMSTR) before being assigned CXCR6 based on its chromosomal location and its similarity to other chemokine receptors in its gene sequence. CXCR7 was originally called RDC-1 (an orphan receptor) but has since been shown to cause chemotaxis in T lymphocytes in response to CXCL12 (the ligand for CXCR4) prompting the renaming of this molecule as CXCR7.

CXCR Isoform Specific Products:

  • CXCR

  • CXCR1

  • CXCR2

  • CXCR3

  • CXCR4

  • CXCR7

CXCR 相关产品 (28):

Cat. No. Product Name Effect Purity
  • HY-16711
    SB225002 Antagonist 99.78%
    SB225002 是一种有效的选择性 CXCR2 非肽拮抗剂,抑制 125I-IL-8 和 CXCR2 结合的 IC50 为 22 nM。
  • HY-15251
    Reparixin Inhibitor 99.98%
    Reparixin是趋化因子受体 CXCR1CXCR2 激活的非竞争性变构抑制剂,IC50 分别为1 和 100 nM。
  • HY-P0171
    Motixafortide Antagonist 98.27%
    Motixafortide (BKT140 4-fluorobenzoyl) 是一种新型的CXCR4拮抗剂,IC50约为1 nM。
  • HY-13406
    TAK-779 Antagonist 99.73%
    TAK-779 是一种有效的,选择性的,非肽类 CCR5CXCR3 拮抗剂,对 CCR5Ki 值为 1.1 nM,同时可以有效地,选择性地抑制 R5 HIV-1,在 MAGI-CCR5 细胞中,EC50EC90 值分别为 1.2 nM 和 5.7 nM。
  • HY-15252
    Reparixin L-lysine salt Inhibitor 99.97%
    Reparixin L-lysine salt是趋化因子受体1/2 (CXCR1/2)活化 的变构抑制剂。
  • HY-111149A
    PS372424 hydrochloride Agonist 98.07%
    PS372424 hydrochloride,CXCL10 的三个氨基酸片段,是一种特异的人 CXCR3 激动剂,具有抗炎活性。在关节炎炎症模型中,PS372424 hydrochloride 可抑制 T 细胞迁移。
  • HY-101458A
    IT1t dihydrochloride Antagonist 99.97%
    IT1t dihydrochloride是高效的CXCR4拮抗剂;抑制CXCL12/CXCR4相互作用的IC50值为2.1 nM。
  • HY-N0011
    Baohuoside I Inhibitor 99.70%
    Baohuoside I 是从朝鲜淫羊藿中得到的黄酮类化合物,作为 CXCR4 的抑制剂,能够抑制 CXCR4 的表达,诱导凋亡,具有抗肿瘤活性。
  • HY-15320
    NBI-74330 Antagonist 99.23%
    NBI-74330 是一种有效的 CXCR3 拮抗剂,能够抑制 (125I)CXCL10 和 (125I)CXCL11 的特异性结合,Ki 值分别为 1.5 和 3.2 nM。
  • HY-P0172A
    ATI-2341 TFA Agonist 98.11%
    ATI-2341 是一种有效的 C-X-C 趋化因子受体 4 型 (CXCR4) 功能选择性变构激动剂,其作为偏向配体起作用,有利于 Gα1激活而不是 Gα13。ATI-2341 激活抑制性异源三聚体 G 蛋白 (Gi) 以促进 cAMP 产生的抑制并诱导钙动员。ATI-2341 是一种有效骨髓多形核中性粒细胞 (PMNs) 和造血干细胞和祖细胞 (HSPCs) 动员剂。
  • HY-15971
    AMD 3465 hexahydrobromide Antagonist 98.79%
    AMD 3465 hexahydrobromide (GENZ-644494 hexahydrobromide) 是一种有效的 CXCR4 拮抗剂,在 SupT1 细胞中,能够抑制 12G5 mAb,CXCL12AF647CXCR4 的结合,IC50 值分别为 0.75 nM 和 18 nM;AMD 3465 同时可有效抑制 X4 HIV 的复制 (IC50,1-10 nM),但对 R5 HIV 病毒无作用。
  • HY-101022
    CXCR2-IN-1 Inhibitor 99.26%
    CXCR2-IN-1是可渗透中枢神经系统的CXCR2拮抗剂,pIC50值为9.3。
  • HY-P1104A
    FC131 TFA Antagonist 99.87%
    FC131 TFA 是一种 CXCR4 拮抗剂,抑制 [125I]-SDF-1 与 CXCR4 结合,IC50 值为 4.5 nM。FC131 TFA 具有抗 HIV 的活性。
  • HY-15462
    SRT3109 Antagonist 99.82%
    SRT3109 是一种 CXCR2 拮抗剂,pIC50 值为 8.2,可用于趋化因子介导的疾病研究。
  • HY-P7061A
    ALX 40-4C Trifluoroacetate Inhibitor
    ALX 40-4C Trifluoroacetate 是一种趋化因子受体 (CXCR4) 抑制剂,能够抑制 SDF-1 与 CXCR4 结合,Ki 值为 1 μM,具有抗 HIV-1 作用;ALX 40-4C Trifluoroacetate 同时为 APJ 受体拮抗剂,IC50 值为 2.9 μM。
  • HY-110318
    VUF11207 fumarate Agonist 98.50%
    VUF11207 fumarate (Compound 29) 是一种 CXCR7 激动剂和高效 CXCR7 (pKi 为 8.1) 配体,可诱导 CXCR7β-arrestin2 募集 (pEC50 为 8.8) 和随后的内在化 (pEC50 为 7.9)。
  • HY-101407
    Nicotinamide N-oxide Antagonist 99.93%
    Nicotinamide N-oxide是生物体内烟酰胺分解代谢物, 是高效选择性的CXCR2受体拮抗剂。
  • HY-13021
    SRT3190 Antagonist 99.32%
    SRT3190 是一种 CXCR2 的拮抗剂,可用于趋化因子介导的疾病研究。
  • HY-16509
    UNBS5162 Antagonist 99.92%
    UNBS5162 是一种广谱的趋化因子配体 CXCL 拮抗剂,具有抗肿瘤活性。
  • HY-107987
    CXCR7 modulator 1 Modulator 99.67%
    CXCR7 modulator 1 (compound 25) 是具有口服活性的、CXCR7 类肽调节剂,其 Ki 值为 9 nM。
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