2. 重组蛋白
  3. Immune Checkpoint Proteins

Immune Checkpoint Proteins  (免疫检查点蛋白)

免疫检查点 (ICP) 分子指的是对免疫应答发挥抑制或刺激作用的配体-受体对。免疫检查点在维持免疫稳态和预防自身免疫中起着重要的免疫调节作用。大多数被报道的免疫检查点蛋白表达于适应性免疫系统的细胞，特别是T细胞和先天免疫系统。
一些肿瘤细胞通过结合共抑制受体分子，限制正常的抗肿瘤免疫反应，从而帮助免疫逃逸。癌症的免疫检查点治疗策略包括了靶向这些调控途径，来恢复免疫细胞的抗肿瘤功能。目前，研究得最广泛的抑制性免疫检查点途径包括了CTLA-4、PD-1 和 PD-L1。

The immune checkpoint (ICP) molecules refer to ligand-receptor pairs that exert inhibitory or stimulatory effects on immune responses. Most of the ICP proteins that have been described are expressed on cells of the adaptive immune system, particularly on T cells, and of the innate immune system. ICPs act as important immune regulators in maintaining immune homeostasis and preventing autoimmunity.
Some cancer cells can bind co-inhibitory receptor molecules to limit normal anti-tumor immune responses, thus assisting in immune escape. Immune checkpoint therapy for cancer encompasses strategies that target these regulatory pathways to reinvigorate the anti-tumor function of immune cells. The most widely studied inhibitory checkpoint pathway consisting of cytotoxic T lymphocyte-associated molecule-4 (CTLA-4), programmed cell death receptor-1 (PD-1), and programmed cell death ligand-1 (PD-L1).

 
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