2. 重组蛋白
  3. Receptor Proteins
  4. Cell Adhesion Molecules (CAMs)

Cell Adhesion Molecules (CAMs)  (细胞粘附分子)

细胞粘附分子 (CAMs) 是介导细胞之间或细胞与胞外基质 (ECM) 结合的细胞表面蛋白。CAMs参与多种细胞过程，包括细胞粘附、识别、信号传导和细胞增殖调控。CAMs是典型的单次跨膜受体，通常由三个保守域构成：与细胞骨架蛋白结合的胞内结构域，胞外结构域，以及跨膜结构域。已知有多种类型的 CAMs，例如钙粘蛋白、选择素、整合素和免疫球蛋白超家族的粘附分子 (如凝集素)。CAMs 又可以分为依赖钙和非依赖钙型CAMs。

Cell adhesion molecules (CAMs) are cell surface proteins that mediate the binding between cells, or between cells and the extracellular matrix (ECM). CAMs are involved in diverse cellular processes, including cell-cell cohesion, recognition, signaling, and the regulation of cell proliferation. CAMs are typically single-pass transmembrane receptors compounded of three domains: an intracellular domain that binds to cytoskeleton proteins, an extracellular domain and a transmembrane domain. There are various types of CAMs are now known, such as cadherins, selectins, integrins, and adhesion molecules of the immunoglobulin superfamily ( IgCAM ) including nectins. CAMs are also classified as calcium-dependent CAMs and calcium-independent CAMs.

 
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