1. Signaling Pathways
  2. Anti-infection
  3. Fungal

Fungal

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal 相关产品 (135):

Cat. No. Product Name Effect Purity
  • HY-12320
    Cycloheximide Inhibitor 99.45%
    Cycloheximide (Naramycin A) 是真核生物蛋白质合成的抑制剂,抑制体内蛋白质合成和RNA合成的 IC50 值分别为532.5 nM 和 2880 nM。
  • HY-B0490
    Hygromycin B Inhibitor >98.00%
    Hygromycin B是抑制原核和真核细胞的氨基糖苷类抗生素。
  • HY-B0221
    Amphotericin B Inhibitor >98.00%
    Amphotericin B是针对多种真菌病原体的多烯抗真菌 (fungal) 剂。 它与麦角甾醇不可逆地结合,导致膜完整性破坏并最终导致细胞死亡。
  • HY-17409
    Nystatin Inhibitor 98.29%
    Nystatin是一种对酵母和支原体有效的多烯抗真菌抗生素。
  • HY-17006
    Caspofungin Acetate Inhibitor 99.79%
    Caspofungin Acetate 是一种抗真菌药,能够非竞争性地抑制1,3-β-d葡聚糖合酶的合成。
  • HY-16909
    Leptomycin B Inhibitor >98.0%
    Leptomycin B (CI 940; LMB) 是一种蛋白出核转运抑制剂。Leptomycin 通过半胱氨酸残基处的共价修饰使 CRM1/exportin 1 失活。 Leptomycin B 是一种有效的抗真菌抗生素,可阻断真核细胞周期。
  • HY-N6718
    Filipin III Inhibitor 99.00%
    Filipin III 是 Filipin 的主要成分,Filipin 是一种 28-元环五烯大环内酯类抗真菌抗生素,由 S. filipinensisS. avermitilisS. miharaensis 产生。Filipin 可以与膜甾醇相互作用导致膜结构的改变。
  • HY-114495
    Caerulomycin A Inhibitor >98.0%
    Caerulomycin A (Cerulomycin; Caerulomycin) 是一种抗真菌 (antifungal) 化合物,能够诱导 T 细胞的产生。Caerulomycin A 能够抑制 IFN-γ 诱导的 STAT1 通路,从而增强 TGF-β-Smad3 信号通路。具有抗真菌和抗细菌活性,可用于自身免疫病的研究。
  • HY-17514
    Itraconazole Inhibitor 99.55%
    Itraconazole是抗真菌剂。
  • HY-B0105
    Ketoconazole Inhibitor 99.67%
    Ketoconazole (R-41400) 是咪唑类抗真菌剂,是经典的CYP3A4抑制剂,也是 CYP24A1的抑制剂。
  • HY-B0101
    Fluconazole Inhibitor 99.51%
    Fluconazole是抗真菌化合物,可用于表面和全身性的真菌感染。
  • HY-14273
    Isavuconazole Inhibitor 99.99%
    Isavuconazole 是一种水溶的苯三唑,具有抗真菌作用,同时也是 CYP3A4 的温和抑制剂。
  • HY-16321
    Micafungin sodium Inhibitor >98.0%
    Micafungin sodium (FK 463 sodium) 是抗真菌剂,抑制1, 3-beta-D-glucan的合成。
  • HY-17373
    Posaconazole Inhibitor 99.91%
    Posaconazole 是一种广谱的,二代三唑类物质,具有抗真菌作用。
  • HY-76200
    Voriconazole Inhibitor 99.97%
    Voriconazole(UK-109496)是第二代三唑类抗真菌化合物,可作用于严重的真菌感染。
  • HY-B0450
    Ciclopirox Inhibitor 98.76%
    Ciclopirox (Penlac)是合成的抗真菌化合物。
  • HY-13553
    Anidulafungin Inhibitor 98.98%
    Anidulafungin 是一种新型的半合成棘球白素,具有抗真菌 (antifungal) 效力。
  • HY-10882
    Clotrimazole Inhibitor 99.62%
    Clotrimazole是咪唑衍生物,有抗真菌活性,是P450抑制剂。
  • HY-17395A
    Terbinafine Inhibitor 99.98%
    Terbinafine (TDT 067) 是治疗真菌感染的抗真菌药物。它是念珠菌属的角鲨烯环氧化酶有效的非竞争性抑制剂, Ki值为30 nM。
  • HY-B0139
    Flucytosine Inhibitor >99.0%
    Flucytosine(5-Fluorocytosine, 5-FC, Ancobon)是抗真菌化合物。
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