1. 重组蛋白
  2. Enzymes & Regulators
  3. Cathepsin

Cathepsin  (组织蛋白酶)

组织蛋白酶 (Cathepsins) 是一种蛋白酶,可以是丝氨酸蛋白酶、半胱氨酸蛋白酶或天冬氨酸蛋白酶。 人类大约有15类组织蛋白酶 (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W,和Z)。所有的组织蛋白酶共享相同的结构支架,称为木瓜蛋白酶样折叠,它包括两个亚结构域,称为L- 和R- 结构域。 活性位点裂口位于 L- 和R- 结构域之间的分子顶部,包含保守的催化二分体 Cys-His。组织蛋白酶在消化、凝血、免疫反应、脂肪生成、激素释放、肽合成等一系列功能中起着至关重要的作用。

Cathepsins are protease that can be serine protease, cysteine protease, or aspartyl protease. There are about 15 classes of cathepsins in humans (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). All the cathepsins share the same structural scaffold, also called the papain-like fold, which consists of two subdomains, referred to as the L- and R-domains. The active site cleft is at the top of the molecule between the L- and R-domains and contains the conserved catalytic dyad Cys-His. Cathepsins are vital for digestion, coagulation, immune response, adipogenesis, hormone liberation, peptide synthesis, among a litany of other functions.

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