Necrotic Cell Death  (坏死性细胞死亡)

别名: Necrosis

Necrotic cell death or cellular necrosis encompasses a wide variety of cell death processes with one common denominator: the loss of plasma membrane integrity followed by cytoplasmic leakage. Necrosis can occur simply as a consequence of such extensive damage that cell integrity is disrupted—for example, at high temperature, following freeze-thaw, or upon mechanical stress. In such cases, cell death is passive and does not require the activation of any particular signaling pathway. Pyroptosis and necroptosis represent two pathways of genetically encoded necrotic cell death.