1. Signaling Pathways
  2. Metabolic Enzyme/Protease
    Neuronal Signaling
  3. Adenosine Kinase

Adenosine Kinase

Adenosine kinase (AK) is a cytosolic enzyme that catalyzes the conversion of adenosine to AMP. One potential adenosine regulating agent (ARA) target is adenosine kinase. Adenosine kinase activation represents the major clearance route of adenosine and is partly responsible for its extremely short plasma half-life (<1 s). Inhibition of adenosine kinase results in increased intracellular adenosine which passes out of the cell via passive diffusion or via nucleoside transporter(s) to activate nearby cell-surface adenosine receptors. Thus, adenosine kinase inhibition can represent an alternative mechanism for activation of adenosine receptors and production of adenosine-associated pharmacologies.

Adenosine kinase inhibitors (AKIs) represent an alternative strategy, since AKIs may raise local adenosine levels in a more site- and event-specific manner and thereby elicit the desired pharmacology with a greater therapeutic window. Several potent AKIs are shown to exhibit anticonvulsant activity in the rat maximal electric shock (MES) induced seizure assay.

Adenosine Kinase 相关产品 (2):

Cat. No. Product Name Effect Purity
  • HY-15424
    5-Iodotubercidin Inhibitor 99.71%
    5-Iodotubercidin (NSC 113939),一种 ATP 类似物,是一种有效的腺苷激酶 (adenosine kinase) 抑制剂,IC50 值为 26 nM。5-Iodotubercidin (NSC 113939) 通过激活磷酸化酶和糖原合成酶,在离体肝细胞中启动糖原合成。5-Iodotubercidin (NSC 113939) 也抑制 CK1、胰岛素受体酪氨酸激酶、磷酸化酶激酶、PKA、CK2、PKC 和 Haspin 抑制剂。
  • HY-103161
    ABT-702 dihydrochloride Inhibitor 98.03%
    ABT-702 dihydrochloride 是一种有效的腺苷激酶 (AK) 抑制剂 (IC50=1.7 nM)。
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