1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Adiponectin Receptor

Adiponectin Receptor (脂联素受体)

Adiponectin is a protein which in humans is encoded by the ADIPOQ gene. It is involved in regulating glucose levels as well as fatty acid breakdown. The hormone plays a role in the suppression of the metabolic derangements that may result intype 2 diabetes, obesity, atherosclerosis, non-alcoholic fatty liver disease and an independent risk factor for metabolic syndrome. Adiponectin binds to a number of receptors. Two receptors have been identified with homology to G protein-coupled receptors, and one receptor similar to the cadherin family: adiponectin receptor 1 and adiponectin receptor 2.

Adiponectin Receptor 相关产品 (4):

目录号 产品名 作用方式 纯度
  • HY-15848
    AdipoRon Agonist 99.87%
    AdipoRon 是可口服的脂联素受体 (AdipoR) 激动剂,能够与 AdipoR1AdipoR2 结合,Kd 值分别为 1.8 μM 和 3.1 μM。
  • HY-N0166
    Gramine

    芦竹碱; 禾草碱

    Agonist 99.63%
    Gramine (Donaxine) 是从芦竹中得到的生物碱,为有效的脂联素受体 (adiponectin receptor (AdipoR)) 激动剂,对 AdipoR2 和 AdipoR1 的 IC50 值分别为 3.2 和 4.2 µM。Gramine 同时为小鼠和人 β2-Adrenergic receptor (β2-AR) 激动剂。Gramine 具有抗肿瘤、抗炎和抗病毒作用。
  • HY-N9182
    Zeaxanthin dipalmitate
    Zeaxanthin dipalmitate (Physalien) 是一种枸杞衍生的类胡萝卜素,具有抗炎和抗氧化应激作用。Zeaxanthin dipalmitate 与 p2X7 受体 (Kd=81.2 nM) 和脂联素受体 1 (AdipoR1; Kd=533 nM) 以正剂量依赖性方式直接相互作用。Zeaxanthin dipalmitate 恢复乙醇中毒抑制的线粒体自噬 (autophagy) 功能。Zeaxanthin dipalmitate 可用于酒精性脂肪肝 (AFLD)、色素性视网膜炎 (RP) 的研究。
  • HY-110164
    AdipoRon hydrochloride Agonist
    AdipoRon hydrochloride 是一种可口服的,特异性的 AdipoR 激动剂,能够与 AdipoR1 和 AdipoR2 结合,Kd 值分别为 1.8 和 3.1 μM。
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