1. Signaling Pathways
  2. GPCR/G Protein
  3. Bombesin Receptor

Bombesin Receptor (蛙皮素受体)

The bombesin (Bn) receptor family includes the gastrin-releasing peptide (GRPR) and neuromedin B (NMBR) receptors, Bn receptor subtype 3 (BRS-3) and Bn receptor subtype 4 (BB4). Activation of these receptors mediates a wide spectrum of biological activities including important changes in the central nervous system including satiety, control of circadian rhythm, thermoregulation, and in peripheral tissues including stimulation of gastrointestinal hormone release, activation of macrophages, and effects on development. Bn-related peptides also have potent growth effects causing proliferation of bothnormal cells and various tumor cell lines.

BRS-3 is receiving increased attention, because not only is it important in a number of gastrointestinal (GI) tract and central nervous system (CNS) processes, but also because it is one of the G-protein coupling receptor families most frequently ectopically or overexpressed by a different tumors, including prostate cancer, small cell lung cancer, breast cancer, CNS tumors, and carcinoids (intestinal, thymic, and bronchial).

Bombesin Receptor 相关产品 (9):

目录号 产品名 作用方式 纯度
  • HY-103286
    PD176252 Antagonist ≥99.0%
    PD176252 是一种有效的 BB1BB2 拮抗剂,能够抑制人 BB1 和 BB2 受体和大鼠 BB1 和 BB2 受体活性,Ki 值分别为 0.17 nM,1 nM 和 0.66 nM,16 nM;PD176252 同时为 FPR1/FPR2 的激动剂,在 HL-60 细胞中,EC50 值分别为 0.31 和 0.66 μM。
  • HY-14342
    MK-5046 Agonist 99.67%
    MK-5046是新型 BRS-3激动剂, 高亲和力与BRS-3结合 (鼠 Ki = 1.6 nM, 人 Ki = 25 nM)。
  • HY-P0195
    Bombesin Modulator 99.76%
    Bombesin 是一种十四肽,在胃泌素释放和 G 蛋白受体活化中起重要作用。
  • HY-P1423A
    BA 1 TFA Agonist 99.65%
    BA 1 TFA 是一种 bombesin (BB) 受体家族激动剂。BA 1 与 Bombesin 受体亚型 3 (BRS3),胃泌素释放肽受体 (GRPR),神经调节素 B 受体 (NMBR) 高亲和力结合,IC50 分别为 6、0.4、2.5 nM 。
  • HY-101844
    ML-18 Antagonist 98.84%
    ML-18是一种抑制肺癌生长的非肽铃蟾肽受体亚型-3 (BRS-3) 拮抗剂。
  • HY-P0107A
    RC-3095 TFA Antagonist
    RC-3095 TFA 是一种选择性蛙皮素 (bombesin)/胃泌素 (gastrin) 释放肽受体拮抗剂。RC-3095 TFA 作用于关节炎小鼠,通过减少胃氧化损伤来发挥保护作用。
  • HY-N2600
    Kuwanon H Antagonist 98.60%
    Kuwanon H 是桑白皮中的黄酮类化合物,为非肽类蛙皮素受体 (bombesin receptor) 拮抗剂。Kuwanon H 可特异性抑制细胞内胃泌激素释放肽 CRP 与(GRP-preferring recepotr) 受体的结合,Ki 值为 290 nM。
  • HY-N4247
    Kuwanon G Antagonist
    Kuwanon G 是从桑树中得到的黄酮类化合物,为蛙皮素受体 (bombesin receptor) 拮抗剂,具有杀菌作用。
  • HY-P1423
    BA 1 Agonist
    BA 1 是一种 bombesin (BB) 受体家族激动剂。BA 1 与 Bombesin 受体亚型 3 (BRS3),胃泌素释放肽受体 (GRPR),神经调节素 B 受体 (NMBR) 高亲和力结合,IC50 分别为 6、0.4、2.5 nM 。
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