1. Signaling Pathways
  2. GPCR/G Protein
  3. Bombesin Receptor

Bombesin Receptor (蛙皮素受体)

Bombesin, a peptide of 14 amino acids, is an amphibian homolog to the mammalian gastrin-releasing peptide (GRP), that has been extensively studied as a targeting ligand for diagnosis and therapy of GRP positive tumors, such as breast, pancreas, lungs and prostate cancers. Bombesin binds to and activates G-protein coupled receptors, known as gastrin releasing peptide receptor (GRPR).

Bombesin, a tetradecapeptide isolated from the skin of the frog Bombina bombina, have shown broad spectrum of biological activities. The BBS activates three G protein-coupled receptors: bombesin receptor 1 (BB1), bombesin receptor 2 (BB2), and bombesin receptor 3 (BB3). BBS-like peptides-Neuromedin B (NB) and gastrin releasing peptide (GRP) are natural ligand of the BB1 and BB2 receptors, respectively.

In mammals, BBS receptors and BBS-like peptides are distributed in the Central Nervous System (CNS) including regions involved in the cardiorespiratory control.

The mammalian bombesin G-protein-coupled receptor subfamily comprises three structurally related members, the receptors for neuromedin B (NMBR or BB1), gastrin-releasing peptide (GRPR or BB2), and bombesin receptor subtype-3 (BRS-3 or BB3).

Bombesin receptor subtype-3 (BRS-3) is an orphan G protein-coupled receptor implicated in the regulation of energy homeostasis.

Bombesin Receptor 相关产品 (8):

目录号 产品名 作用方式 纯度
  • HY-103286
    PD176252 Antagonist ≥99.0%
    PD176252 是一种有效的 BB1BB2 拮抗剂,能够抑制人 BB1 和 BB2 受体和大鼠 BB1 和 BB2 受体活性,Ki 值分别为 0.17 nM,1 nM 和 0.66 nM,16 nM;PD176252 同时为 FPR1/FPR2 的激动剂,在 HL-60 细胞中,EC50 值分别为 0.31 和 0.66 μM。
  • HY-P0195
    Bombesin Modulator 99.76%
    Bombesin 是一种十四肽,在胃泌素释放和 G 蛋白受体活化中起重要作用。
  • HY-P1423A
    BA 1 TFA Agonist 99.65%
    BA 1 TFA 是一种 bombesin (BB) 受体家族激动剂。BA 1 与 Bombesin 受体亚型 3 (BRS3),胃泌素释放肽受体 (GRPR),神经调节素 B 受体 (NMBR) 高亲和力结合,IC50 分别为 6、0.4、2.5 nM 。
  • HY-101844
    ML-18 Antagonist 98.84%
    ML-18是一种抑制肺癌生长的非肽铃蟾肽受体亚型-3 (BRS-3) 拮抗剂。
  • HY-N2600
    Kuwanon H Antagonist
    Kuwanon H 是桑白皮中的黄酮类化合物,为非肽类蛙皮素受体 (bombesin receptor) 拮抗剂。Kuwanon H 可特异性抑制细胞内胃泌激素释放肽 CRP 与(GRP-preferring recepotr) 受体的结合,Ki 值为 290 nM。
  • HY-P0107A
    RC-3095 TFA Antagonist
    RC-3095 TFA 是一种蛙皮素 (bombesin)/胃泌素 (gastrin) 释放肽受体拮抗剂。RC-3095 TFA 作用于关节炎小鼠,通过减少胃氧化损伤来发挥保护作用。
  • HY-N4247
    Kuwanon G Antagonist
    Kuwanon G 是从桑树中得到的黄酮类化合物,为蛙皮素受体 (bombesin receptor) 拮抗剂,具有杀菌作用。
  • HY-P1423
    BA 1 Agonist
    BA 1 是一种 bombesin (BB) 受体家族激动剂。BA 1 与 Bombesin 受体亚型 3 (BRS3),胃泌素释放肽受体 (GRPR),神经调节素 B 受体 (NMBR) 高亲和力结合,IC50 分别为 6、0.4、2.5 nM 。
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