Glucose-6-Phosphate Isomerase (GPI) 

Glucose-6-Phosphate Isomerase (GPI), the second enzyme in the glycolytic pathway, is a dimeric enzyme that catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate. Glucose-6-Phosphate Isomerase has been linked to the proliferation and motility of cancer cells via its control over glucose-6-phosphate levels. Aside from being a glycolytic intermediate, it has been seen that in certain cancers glucose-6-phosphate can act as a tumor secreted-cytokine as well as an angiogenesis-promoting factor. Moreover, Glucose-6-Phosphate Isomerase induces the expression of a matrix metalloproteinase-3 protein in some cancer cells, which subsequently increases tumor invasiveness^[1].