1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)

Isocitrate Dehydrogenase (IDH) (异柠檬酸脱氢酶)

Isocitrate dehydrogenase (IDH), one of the key enzymes in the citric acid cycle, catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (α-KG) generating carbon dioxide and NADPH/NADH. IDHs belong to a large ancient family of enzymes that play central roles in energy metabolism, amino acid biosynthesis and vitamin production.

IDH protein family consists of three self-regulating enzymes (IDH1, IDH2, and IDH3). IDH1 and IDH2 are both nicotinamide adenine dinucleotide phosphate (NADP)-dependent enzymes that catalyze the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (α-KG), while producing NADPH either in peroxisomes and the cytosol (IDH1) or in mitochondria (IDH2). IDH3 catalyzes the same reaction in the mitochondria, but in a NAD-dependent fashion. Mutations in IDH1 and IDH2 have been demonstrated in a variety of malignancies. IDH inhibitors have engendered hope in IDH1/2 mutant myeloid malignancies.

Isocitrate Dehydrogenase (IDH) 相关产品 (5):

目录号 产品名 作用方式 纯度
  • HY-19540
    GSK864 Inhibitor 99.68%
    GSK864是异柠檬酸脱氢酶1 (IDH1) 突变体抑制剂; 抑制IDH1突变体R132C,R132H和R132G的IC50值分别为8.8,15.2和16.6 nM。
  • HY-12475
    Mutant IDH1-IN-1 Inhibitor 99.60%
    Mutant IDH1-IN-1是 IDH1 突变体的选择性抑制剂,对突变体IDH1 R132C/R132C,IDH1 R132H/R132H,IDH1 R132H/WT和野生型IDH1的 IC50 值分别为4, 42, 80 和 143 nM。
  • HY-18717
    Mutant IDH1-IN-2 Inhibitor ≥98.0%
    Mutant IDH1-IN-2是一种突变型异柠檬酸脱氢酶 (IDH) 蛋白抑制剂, 在LS-MS生物化学检测中IC50值为<22 nM, 荧光生物化学检测中IC50值为16.6 nM。
  • HY-112601
    IDH1 Inhibitor 1 Inhibitor
    IDH1 Inhibitor 1 是一种有效的,口服生物可利用的,脑渗透性,选择性突变 IDH1 抑制剂,抑制 IDH1R132HIDH1R132C,和 IDH1WTIC50 分别为 0.021 μM, 0.045 μM, 和 2.52 μM。具有抗肿瘤活性。
  • HY-114459
    Mutant IDH1-IN-4 Inhibitor ≥99.0%
    Mutant IDH1-IN-4 (compound 434) 是一种突变型异柠檬酸脱氢酶 1 (IDH 1) 的抑制剂,其对R132H、HT1080 和U87R132H细胞中的突变型IDH 1 的IC50 值 ≤ 0.5 μM。
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