1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. Na+/HCO3- Cotransporter

Na+/HCO3- Cotransporter (Na+/HCO3-共转运体)

Na/HCO3 cotransporter; NBC

The electrogenic Na/HCO3 cotransporter (symporter) is the major HCO3- transporter of the renal proximal tubule (PiT), located at the basolateral membrane (BLM), and also plays a noteworthy role in Na+ reabsorption. HCO3 transporters are important for regulation of intracellular pH (pHi) in most cells and also thereby regulate blood pH. This electrogenic Na/HCO3 cotransporter is first discovered using perfused Ambystoma tigrinum (salamander) renal, proximal tubules. This novel cotransporter mediates the movement of one Na+ ion with several HCO3- ions, making it electrogenic, is blocked by stilbene compounds, but does not depend on intra- or extracellular Cl-. This and similar cotransporters have been found in a number of tissues and cell types.

Na+/HCO3- Cotransporter 相关产品 (1):

目录号 产品名 作用方式 纯度
  • HY-15529
    S0859 Inhibitor 99.69%
    S0859 是一种选择性的,高亲和力的 Na+/HCO3- 共转运体 (NBC) 抑制剂,可逆性地抑制 NBC 介导的细胞内 pH (pHi) 恢复 (Ki=1.7 μM,完全抑制在 30 μM)。