1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. Neurokinin Receptor

Neurokinin Receptor

There are three main classes of neurokinin receptors: NK1R (the substance P preferring receptor), NK2R, and NK3R. These tachykinin receptors belong to the class I (rhodopsin-like) G-protein coupled receptor (GPCR) family. The various tachykinins have different binding affinities to the neurokinin receptors: NK1R, NK2R, and NK3R. These neurokinin receptors are in the superfamily of transmembrane G-protein coupled receptors (GPCR) and contain seven transmembrane loops. Neurokinin-1 receptor interacts with the Gαq-protein and induces activation of phospholipase C followed by production of inositol triphosphate (IP3) leading to elevation of intracellular calcium as a second messenger. Further, cyclic AMP (cAMP) is stimulated by NK1R coupled to the Gαs-protein. The neurokinin receptors are expressed on many cell types and tissues.

Neurokinin Receptor 相关产品 (53):

Cat. No. Product Name Effect Purity
  • HY-P0201
    Substance P Modulator 98.07%
    Substance P 是一种神经肽,作为神经递质和神经调节剂。Substance P 的内源性受体是神经激肽1受体 (neurokinin 1 receptorNK1R)。
  • HY-10052
    Aprepitant Inhibitor 99.93%
    Aprepitant (MK-0869) 是选择性和高亲和力的神经激肽1受体拮抗剂,Kd 值为86 pM。
  • HY-15722
    SB-222200 Antagonist 99.91%
    SB 222200是可逆的竞争性人NK受体抑制剂,对hNK-3受体的Ki为4.4 nM,能透过血脑屏障。
  • HY-19632
    Fezolinetant Antagonist 98.29%
    Fezolinetant 是一种神经激肽-3 受体 (neurokinin 3 receptor) 拮抗剂,可用于更年期潮热的研究。
  • HY-P0187
    Senktide Agonist 99.56%
    Senktide 是一种速激肽 NK3 受体激动剂。
  • HY-P0242A
    Neurokinin B TFA Agonist
    Neurokinin B TFA 属于速激肽家族。Neurokinin 结合到一系列 G 蛋白偶联受体 (GPCR)-包括神经激肽受体1 (NK1R),NK2R 和 NK3R,且介导其生物学作用。
  • HY-107691
    GR 159897 Antagonist
    GR 159897 是一种有效、选择性,竞争性、可通过血脑屏障的非多肽类速激肽受体 (tachykinin NK2 receptors) 拮抗剂,抑制 [3H]GR100679 与 表达 hNK2 的 CHO 细胞及大鼠结肠膜的结合,pKi 值分别为 9.51 和 10。拮抗支气管收缩,具有抗焦虑作用。
  • HY-P1012A
    [Sar9,Met(O2)11]-Substance P (TFA) Agonist 99.68%
    [Sar9,Met(O2)11]-Substance P TFA 是一种选择性的速激肽 NK1 受体激动剂。
  • HY-P1012
    [Sar9,Met(O2)11]-Substance P Agonist 98.45%
    [Sar9,Met(O2)11]-Substance P 是一种选择性的速激肽 NK1 受体激动剂。
  • HY-14432
    Pavinetant Antagonist 99.74%
    Pavinetant (MLE-4901) 是一种神经激肽-3 受体 (NK3R) 拮抗剂。
  • HY-10053
    Maropitant Antagonist 99.00%
  • HY-14407A
    Fosaprepitant dimeglumine Antagonist >99.0%
    Fosaprepitant dimeglumine(MK-0517)是神经激肽-1受体拮抗剂,可作用于化疗引起的恶心呕吐。
  • HY-14552
    Talnetant Antagonist 99.43%
    Talnetant (SB 223412)是高活性NK3受体选择性拮抗剂,Ki为1.4 nM,比对hNK-2受体的抑制性高100倍,对hNK-1无亲和性。
  • HY-14751
    Rolapitant Antagonist 98.01%
    Rolapitant (SCH619734)是高效选择性具有口服活性的 neurokinin NK1 受体抑制剂,Ki值为0.66 nM。
  • HY-16346
    Netupitant Antagonist 99.78%
    Netupitant (CID-6451149) 是一高效、选择性、口服活性的Neurokinin-1受体(NK1)拮抗剂,Ki值为0.95nM。
  • HY-18006
    NKP608 Antagonist 99.34%
    NKP608为非肽类4-氨基哌啶衍生物,是神经激肽-1(NK-1)受体拮抗剂,IC50为2.6 nM。
  • HY-P1276A
    Men 10376 TFA Antagonist 99.76%
    Men 10376 TFA 是一种有效的选择性的 tachykinin NK-2 受体拮抗剂,对大鼠小肠 NK-2 受体的 Ki 值为 4.4 μM。
  • HY-P0197
    Neurokinin A 98.92%
    Neurokinin A 通过 NK-2 受体发挥作用。
  • HY-P1031
    [bAla8]-Neurokinin A(4-10) Agonist 98.17%
    [bAla8]-Neurokinin A(4-10) 是一种神经激肽-2 受体 (neurokinin 2 receptor) 激动剂。
  • HY-P1485
    Substance P 1-7
    Substance P (7-11) 是神经肽P物质 (SP) 的片段。Substance P (7-11) 可对孤束核产生抑制和缓和作用。
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