1. Signaling Pathways
  2. Immunology/Inflammation
  3. Thrombopoietin Receptor

Thrombopoietin Receptor

Thrombopoietin (TPO) is the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

TPO binds to the thrombopoietin receptor (TPOr, also termed c-mpl) on platelets, megakaryocytes, and pluripotent stem cells leading to inhibition of apoptosis of stem cells and megakaryocytes; increased megakaryocyte number, size, and ploidy; increased rate of megakaryocyte maturation and platelet count; and decreased platelet threshold for activation by ADP and collagen.

Thrombopoietin Receptor 相关产品 (5):

Cat. No. Product Name Effect Purity
  • HY-15306
    Eltrombopag Agonist 99.82%
    Eltrombopag (SB-497115) 是一种血小板生成素 (TPO) 受体激动剂,用于血小板减少的某些病症研究。
  • HY-15306A
    Eltrombopag Olamine Agonist 99.56%
    Eltrombopag Olamine (SB-497115 Olamine) 是一种血小板生成素 (TPO) 受体激动剂,用于血小板减少的某些病症研究。
  • HY-19883
    Lusutrombopag Agonist 99.09%
    Lusutrombopag 是一种可口服的血小板生成素受体 (thrombopoietin receptor) 激动剂,有潜力用于慢性肝病的研究。
  • HY-100380
    TPO agonist 1 Agonist
    TPO agonist 1 是一种 TPO 激动剂,可用作血小板生成和巨核细胞生成的促进剂,可用于血小板减少症的研究。详细信息请参考专利文献 WO2008134338A1 中的化合物 TPO mimetic。
  • HY-13463B
    Avatrombopag hydrochloride Agonist 98.05%
    Avatrombopag (AKR-501) hydrochloride 是一种口服活性的非肽血小板生成素受体 (TPO receptor) 激动剂 (EC50=3.3 nM)。Avatrombopag hydrochloride 可模拟TPO 的生物活性。Avatrombopag hydrochloride 通过激活细胞内信号传导系统来增加血小板的产生,并促进造血前体细胞产生血小板和巨核细胞。Avatrombopag hydrochloride 是细胞色素 P450 (CYP) 2C9 和 CYP3A 的底物。
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