1. Signaling Pathways
  2. BTB/POZ Family

BTB/POZ Family (BTB/POZ 家族)

BTB/POZ Family

BTB/POZ 家族成员是指含有 BTB/POZ 结构域的蛋白,BTB/POZ 结构域是高度保守的蛋白-蛋白相互作用结构域,该结构域通常位于蛋白的 N 端,核心由 β-折叠 (β1-β4) 和 α-螺旋 (α1-α5) 组成,可与C2H2 锌指、Kelch 结构域、MATH 结构域等结合形成复合蛋白。
BTB/POZ 家族成员具有转录调控、染色质重塑、蛋白降解及离子通道调节等多种功能。BTB/POZ 家族成员可参与泛素-蛋白酶体降解途径,其中Cullin3-E3 泛素连接酶复合体通过 BTB 结构域招募底物蛋白进行泛素化。此外,BTB/POZ 家族成员还在免疫调节、细胞周期控制和凋亡中发挥重要作用。例如,在 ZBTB 家族中,BTB/POZ 结构域可与共抑制因子 (如 NCOR、BCOR、SMRT) 结合,调控基因表达。
BTB/POZ 家族成员的异常活化与多种肿瘤相关,如弥漫性大 B 细胞淋巴瘤 (DLBCL)、白血病、乳腺癌等。此外,BTB/POZ 家族成员在神经退行性疾病和免疫性疾病中也发挥关键作用[1]

BTB/POZ family members refer to proteins containing the BTB/POZ domain, which is a highly conserved protein-protein interaction domain typically located at the N-terminus of proteins. The core of this domain consists of β-sheets (β1-β4) and α-helices (α1-α5) and can associate with C2H2 zinc fingers, Kelch domains, MATH domains, and other structures to form multiprotein complexes.
BTB/POZ family members perform diverse functions, including transcriptional regulation, chromatin remodeling, protein degradation, and ion channel regulation. They are involved in the ubiquitin-proteasome degradation pathway, where the Cullin3-E3 ubiquitin ligase complex recruits substrate proteins for ubiquitination via the BTB domain. Additionally, BTB/POZ proteins play crucial roles in immune regulation, cell cycle control, and apoptosis. For example, in the ZBTB family, the BTB/POZ domain interacts with co-repressors such as NCOR, BCOR, and SMRT, thereby regulating gene expression.
Dysregulation of BTB/POZ family members is associated with various cancers, including diffuse large B-cell lymphoma (DLBCL), leukemia, and breast cancer. Moreover, these proteins are implicated in neurodegenerative disorders and immune-related diseases, highlighting their significance as potential therapeutic targets[1].

BTB/POZ Family 相关产品 (2):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-128577
    NIC3 Inhibitor 99.80%
    NIC3 是一种选择性的伏隔核相关蛋白 1 (NAC1) 抑制剂,与 NAC1 的保守位点 Leu-90 结合,阻止其同源二聚化,导致蛋白酶体 NAC1 的降解。具有抗肿瘤活性。
    NIC3
  • HY-173198
    Kaiso-IN-1 Inhibitor
    Kaiso-IN-1 (Compound 20) 是一种 Kaiso 抑制剂,对 A549 细胞的 IC50 为 0.34 μM。Kaiso-IN-1 可用于肺癌相关领域的研究。
    Kaiso-IN-1