2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Galactokinase

Galactokinase (半乳糖激酶)

Galactokinase; GALK; GAL; GALK1; GAL1

半乳糖激酶是参与半乳糖代谢的关键酶，主要负责将半乳糖磷酸化为半乳糖-1-磷酸。半乳糖激酶功能障碍会导致代谢疾病，如常染色体隐性遗传病半乳糖血症，其中代谢异常的半乳糖及其代谢物在体内积聚，可能导致智力障碍、肝功能障碍和白内障[1]。

Galactokinase is a key enzyme involved in galactose metabolism, mainly responsible for phosphorylating galactose to galactose-1-phosphate. Galactokinasedysfunction leads to metabolic disorders such as the autosomal recessive genetic disease galactosemia, in which abnormal metabolized galactose and its metabolite accumulates in the body, causing probably intellectual disability, liver dysfunction and cataracts[1].

Galactokinase 相关产品 (1):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-173642
    NCGC00238624 Inhibitor
    NCGC00238624 是一种选择性半乳糖激酶 (GALK1) 抑制剂，对人和小鼠重组 GALK1 的 IC50 分别为 7.69 μM 和 13.67 μM。NCGC00238624 在 10 μM 浓度下对 GALK2 和其他激酶无活性。NCGC00238624 可用于经典半乳糖血症的研究。
    NCGC00238624
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