1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Glyoxalase (GLO)

Glyoxalase (GLO) (乙二醛酶)

The glyoxalase system is critical for the detoxification of advanced glycation end-products (AGEs). AGEs are toxic compounds resulting from the non-enzymatic modification of biomolecules by sugars or their metabolites through a process called glycation. AGEs have adverse effects on many tissues, playing a pathogenic role in the progression of molecular and cellular aging.

The glyoxalase system consists of two cooperating enzymes named Glyoxalase 1 (Glo1) and Glyoxalase 2 (Glo2). Glo1 converts a non-enzymatically formed hemithioacetal, the adduct between an intracellular thiol such as glutathione (GSH) and a metabolically produced α-ketoaldehyde such as MG, into a thioester product . In the case of MG and GSH, S-D-lactoylglutathione is the product. Glo2 hydrolyzes this thioester into D-lactate and regenerates the intracellular thiol GSH. Glo1 and Glo2 work in tandem to convert cytoxic MG into D-lactate.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15167A
    Glyoxalase I inhibitor free base Inhibitor 98.52%
    Glyoxalase I inhibitor (free base)是乙二醛酶I (GLO1) 抑制剂, 具有抗癌活性。
    Glyoxalase I inhibitor free base
  • HY-136684
    BrBzGCp2 Inhibitor 98.68%
    BrBzGCp2 是乙二醛酶 1 (GLO1) 的抑制剂,其 GC50 为 4.23 μM (HL-60 细胞)。BrBzGCp2 具有抗肿瘤和神经保护活性。
    BrBzGCp2
  • HY-W009177
    S-Methylglutathione

    S-甲基谷胱甘肽

    Inhibitor ≥99.0%
    S-Methylglutathione 是一种 S 取代的谷胱甘肽,一种比 GSH 更强的亲核试剂 (nucleophile)。S-Methylglutathione 对乙二醛酶 1 (glyoxalase 1) 有抑制作用。
    S-Methylglutathione
  • HY-147648
    Glyoxalase I inhibitor 6 Inhibitor 99.26%
    Glyoxalase I inhibitor 6 (Compound 9j) 是一种 glyoxalase I (Glo-I) 抑制剂,IC50 值为 1.13 μM。Glyoxalase I inhibitor 6 可用作抗癌剂,具有低毒性。
    Glyoxalase I inhibitor 6
  • HY-146655
    Glyoxalase I inhibitor 3 Inhibitor 98.06%
    Glyoxalase I inhibitor 3 (compound 22g) 是一种有效的 乙二醛酶 I (GLO1) 抑制剂,IC50 为 0.011 µM。Glyoxalase I inhibitor 3具有研究抑郁和焦虑的潜力。
    Glyoxalase I inhibitor 3
  • HY-147647
    Glyoxalase I inhibitor 5 98.07%
    Glyoxalase I inhibitor 5 (Compound 9h) 是一种 glyoxalase I (Glo-I) 抑制剂,IC50 值为 1.28 μM。Glyoxalase I inhibitor 5 可用作抗癌剂。
    Glyoxalase I inhibitor 5
  • HY-15167
    Glyoxalase I inhibitor Inhibitor ≥98.0%
    Glyoxalase I inhibitor是乙二醛酶I抑制剂,具有抗癌活性。
    Glyoxalase I inhibitor
  • HY-146653
    Glyoxalase I inhibitor 1 Inhibitor
    Glyoxalase I inhibitor 1 (compound 23) 是一种有效的 glyoxalase I (GLO1) 抑制剂,IC50 为 26 nM。Glyoxalase I inhibitor 1 是一种点击化学试剂。它含有 Alkyne 基团,可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。
    Glyoxalase I inhibitor 1
  • HY-P4277
    N,S-Bis-Fmoc-Glutathione Inhibitor
    N,S-Bis-Fmoc-Glutathione 是一种有效的 glyoxalase II 抑制剂,Ki 值为 0.32 mM。
    N,S-Bis-Fmoc-Glutathione
  • HY-146654
    Glyoxalase I inhibitor 2 Inhibitor
    Glyoxalase I inhibitor 2 (compound 26) 是一种有效的 glyoxalase I (GLO1) 抑制剂,IC50 为 0.5 µM。Glyoxalase I inhibitor 2 具有研究抑郁和焦虑的潜力。
    Glyoxalase I inhibitor 2
  • HY-146656
    Glyoxalase I inhibitor 4 Inhibitor
    Glyoxalase I inhibitor 4 (compound 14) 是一种有效的 乙二醛酶 I (GLO1) 抑制剂,Ki 为 10 nM。
    Glyoxalase I inhibitor 4
  • HY-124824
    Methyl gerfelin Inhibitor
    Methyl gerfelin 通过结合 3 种主要的细胞蛋白来抑制破骨细胞的分化:乙二醛酶 1 (GLO1)、固醇结合蛋白 2 (SCP2) 和富含谷氨酰胺的四肽重复重复蛋白 A (SGTA)。Methyl gerfelin 已被证实是一种与类黄酮类有关的强效 GLO1 抑制剂。
    Methyl gerfelin
  • HY-146657
    4BAB Inhibitor
    4BAB (compound 29) 是一种不可逆的乙二醛酶 I (GLO1) 抑制剂。4BAB 具有抗癌作用。
    4BAB
  • HY-147649
    Glyoxalase I inhibitor 7 Inhibitor
    Glyoxalase I inhibitor 7 (Compound 6) 是一种 glyoxalase I (Glo-I) 抑制剂,IC50 值为 3.65 μM。Glyoxalase I inhibitor 7 可用作抗癌剂。
    Glyoxalase I inhibitor 7
  • HY-146656S
    S-Sulfo-DL-cysteine-2,3,3-d3
    S-Sulfo-DL-cysteine-2,3,3-d3 是 S-Sulfo-DL-cysteine-2,3,3 氘代物。
    S-Sulfo-DL-cysteine-2,3,3-d<sub>3</sub>
  • HY-148216
    HBPC–GSH Inhibitor
    HBPC-GSH 是一种糖醛酸酶 (Glo) 抑制剂 (cGloI IC50=0.6 μM; cGloII IC50=1.6 μM),是谷胱甘肽的衍生物,HBPC-GSH 可用于抗疟疾研究。
    HBPC–GSH
  • HY-115915
    TS010 Inhibitor
    TS010 是一种有效的 GLO-I 抑制剂,IC50 为 0.57 μM。TS010 具有研究癌症疾病的潜力。
    TS010
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