1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Malonyl-CoA Decarboxylase

Malonyl-CoA Decarboxylase (丙二酰辅酶 A 脱羧酶)

MCD

丙二酰辅酶A脱羧酶 (Malonyl-CoA decarboxylase, MCD) 负责催化 Malonyl-CoA 分解成 Acetyl-CoA 和二氧化碳,在脂肪酸的氧化与合成过程中具有调节作用。Malonyl-CoA 不仅是脂肪酸合成的前体,同时也能抑制脂肪酸进入线粒体进行 β-氧化,通过抑制 MCD 活性可以增加心肌中的 Malonyl-CoA 含量,从而降低脂肪酸氧化率并增加丙酮酸氧化。这种代谢改变有助于提升心脏功能和效率,尤其是在心脏缺血的情况下,这种策略显示出其研究缺血性心脏病的潜力。
MCD 的活性也与肥胖和能量代谢紊乱有关。研究显示,SIRT4 酶可通过去乙酰化 MCD 降低其活性,从而调节 Malonyl-CoA 的浓度,平衡脂肪酸的合成与分解。SIRT4 缺失的小鼠展示出提高的运动耐力和对高脂饮食诱导的肥胖的抵抗,标明 MCD 在调控能量代谢和体重管理中的关键作用。
此外,在肺动脉高压的研究中,缺乏 MCD 的小鼠在低氧环境下不表现出肺动脉收缩,且在慢性低氧环境下不发展成肺动脉高压,表明 MCD 的抑制可能通过改变脂肪酸和糖的代谢平衡来防止与肺动脉高压相关的血管重塑和细胞抗凋亡现象。
调节 MCD 活性为心脏病、肺动脉高压以及代谢性疾病研究提供了新的方向[1][2][3]

Malonyl-CoA Decarboxylase (MCD) is responsible for catalyzing the decomposition of Malonyl-CoA into Acetyl-CoA and carbon dioxide, playing a regulatory role in the oxidation and synthesis of fatty acids. Malonyl-CoA is not only a precursor for fatty acid synthesis but also inhibits the entry of fatty acids into mitochondria for β-oxidation. Inhibiting MCD activity can increase the content of Malonyl-CoA in the myocardium, thereby reducing the rate of fatty acid oxidation and increasing pyruvate oxidation. This metabolic change helps enhance heart function and efficiency, especially under conditions of cardiac ischemia, demonstrating potential in research into ischemic heart diseases.
MCD activity is also related to obesity and metabolic disorders. Studies show that the enzyme SIRT4 can deacetylate MCD, reducing its activity, thereby regulating the concentration of Malonyl-CoA and balancing the synthesis and decomposition of fatty acids. Mice lacking SIRT4 exhibit increased exercise endurance and resistance to diet-induced obesity, highlighting the critical role of MCD in regulating energy metabolism and weight management.
Furthermore, in studies on pulmonary hypertension, mice lacking MCD do not exhibit pulmonary artery constriction in low-oxygen environments and do not develop pulmonary hypertension under chronic hypoxia. This suggests that inhibiting MCD may prevent vascular remodeling and apoptosis associated with pulmonary hypertension by altering the balance of fatty acid and sugar metabolism.
Regulating MCD activity provides a new direction for research into heart diseases, pulmonary hypertension, and metabolic disorders[1][2][3].

Malonyl-CoA Decarboxylase 相关产品 (1):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-125748
    CBM-301940 Inhibitor 99.4%
    CBM-301940 (compound 5) 是一种具有口服活性对丙二酸辅酶 A 脱羧酶 (MCD) 抑制剂,IC50 值为 23 nM。CBM-301940 可用于心血管疾病的研究。
    CBM-301940