1. Signaling Pathways
  2. SLK

SLK (STE20 样激酶)

STE20-like kinase

STE20 样激酶 (SLK) 属于丝氨酸/苏氨酸蛋白激酶家族。SLK 可被 G 蛋白偶联受体 (GPCR) 释放的 Gβγ 异二聚体激活。SLK 具有 N 端 Ste20 催化激酶结构域(氨基酸 1-338)、预测的中央非结构化区域(氨基酸 339-788)和 C 端卷曲螺旋结构域(氨基酸 789-1202)。SLK 在细胞迁移、细胞周期控制、细胞死亡、发育、再生过程和癌症等生物过程中发挥关键作用。

STE20-like kinase (SLK) belongs to the Serine/threonine protein kinase family. SLK can be activated by Gβγ heterodimers released by G protein-coupled receptors (GPCRs). SLK displays an N-terminal Ste20 catalytic kinase domain (amino acids 1–338), a predicted central unstructured region (amino acids 339–788), and a C-terminal coiled-coil domain (amino acids 789–1202). SLK play key roles in biological processes such as cell migration, cell cycle control, cell death, development, regenerative processes, and cancer[1].

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Cat. No. Product Name Effect Purity Chemical Structure