1. Anti-infection
  2. Fungal
  3. ASP2397

ASP2397 (Synonyms: VL-2397)

目录号: HY-125882
产品使用指南

ASP2397 (VL-2397) 是一种天然产物,对 Aspergillus 具有快速有效的杀菌活性,人血清中的MIC 值为1-4 μg/mL。ASP2397 (VL-2397) 具有治疗侵袭性肺曲菌病 (IPA) 的潜力。

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ASP2397 Chemical Structure

ASP2397 Chemical Structure

CAS No. : 2088622-19-7

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Description

ASP2397 (VL-2397), a natural compound, exhibits rapid and potent fungicidal activity against Aspergillus species, at a MIC range of 1 to 4 μg/mL in human serum. ASP2397 (VL-2397) has the potential to treat invasive pulmonary aspergillosis (IPA)[1].

IC50 & Target

MIC: 1-4 μg/mL (Aspergillus species)[1].

In Vivo

ASP2397 (1, 2, 4, or 8 mg/kg, s.c., b.i.d.) significantly improves survival in IPA models in mice[1].

Animal Model: A mouse model of A. fumigatus-induced IPA[1].
Dosage: 1, 2, 4, 8 mg/kg.
Administration: S.C., BID, from day 1 for 3 days.
Result: Significantly improved survival.
Molecular Weight

914.94

Formula

C₄₀H₅₉AlN₁₀O₁₃

CAS No.

2088622-19-7

SMILES

O=C(N[C@@H](CCCN1C(C)=O[Al+3]23(O[N-](CCC4)C(C)=O2)([O-]N(CCC5)C(C)=O3)[O-]1)C(N[C@@H]5C(N[C@@H]4C(N[C@@H](CC(N)=O)C(N[C@H]6CC(C)C)=O)=O)=O)=O)[C@H](NC6=O)CC7=CC=CC=C7

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
ASP2397
目录号:
HY-125882
需求量:

ASP2397

Cat. No.: HY-125882