1. Biology Dictionary
  2. Cyclophilin A (CypA)

Cyclophilin A (CypA)亲环素 A

释义:

Cyclophilin A (CypA), a key member of the immunophilin family, is the most abundantly expressed isozyme of the 18 known human cyclophilins. Besides acting as an intracellular receptor for cyclosporine A, CypA plays a vital role in microorganismal infections, cardiovascular diseases, liver diseases, kidney diseases, neurodegeneration, cancer, rheumatoid arthritis, periodontitis, sepsis, asthma, and aging.

亲环素 A (CypA) 是亲免疫素家族的关键成员,是已知的 18 种人类亲环素中表达最多的同工酶。除了作为环孢素A的细胞内受体外,CypA 在微生物感染、心血管疾病、肝脏疾病、肾脏疾病、神经退行性变、癌症、类风湿性关节炎、牙周炎、败血症、哮喘和衰老中起着至关重要的作用。

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