1. Biology Dictionary
  2. Maximum tolerated dose (MTD)

Maximum tolerated dose (MTD)最大耐受剂量

释义:

Maximum tolerated dose (MTD) refers to the maximum dose that a chemical tolerated does not cause death of the tested subjects (experimental animals) in the acute toxicity test of foreign compounds. Beyond which a specific toxicity or action can not be attributed to a test substance due to the compromised state of the organism. MTD is often used as a basis for the selection of dose ranges in acute toxicity tests.

最大耐受剂量(MTD) 是指在外来化合物的急性毒性试验中,一种化学物质不会导致受试对象(实验动物)死亡的最大耐受剂量。 超出此范围,由于生物体的受损状态,特定的毒性或作用不能归因于测试物质。 MTD 通常用作急性毒性试验中选择剂量范围的基础。

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