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  2. Mitochondrial disease

Mitochondrial disease线粒体疾病

释义:

Mitochondrial diseases are clinically heterogeneous group of disorders that arise as a result of dysfunction of the mitochondria. They can be caused by mutation of genes encoded by either nuclear DNA or mitochondrial DNA. While some mitochondrial disorders only affect a single organ, most of them involve multiple organ systems and often present with prominent neurologic and myopathic features.

线粒体疾病是由于线粒体功能障碍而引起的一组临床异质性疾病。它们可能是由核 DNA 或线粒体 DNA 编码的基因突变引起的。虽然一些线粒体疾病仅影响单个器官,但大多数线粒体疾病涉及多个器官系统,并且通常具有突出的神经和肌病特征。

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