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  2. Presenilin 2 (PS2)

Presenilin 2 (PS2)早老素-2

释义:

Presenilin-2 (PS2) is one of the three proteins that are dominantly mutated in familial Alzheimer's disease (FAD). It forms the catalytic core of the γ-secretase , independently of γ-secretase activity, in the modulation of several cellular processes, such as Ca2+ signalling, mitochondrial function, inter-organelle communication, and autophagy.

早老素-2 (PS2) 是家族性阿尔茨海默病 (FAD) 中主要突变的三种蛋白质之一。它形成了 γ-分泌酶的催化核心,独立于 γ-分泌酶活性,调节几个细胞过程,如 Ca2+ 信号,线粒体功能,细胞器间通信和自噬。

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