2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Deglycobleomycin

Deglycobleomycin 是一种靶向 r(CUG) 重复序列的 RNA 切割剂。Deglycobleomycin 与识别 r(CUG)exp 的小分子结合后，能选择性地切割 r(CUG)exp。Deglycobleomycin 对 DNA 的切割效率远低于Bleomycin A5 (Pingyangmycin) (HY-N10470)。但 Deglycobleomycin 具有增强的对 r(CUG)exp 的选择性切割活性。Deglycobleomycin 可用于 r(CUG) 重复序列扩张引起的相关疾病 (如 1 型强直性肌营养不良) 的研究；并用于精准靶向切割致病 RNA 的药物研发。

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Deglycobleomycin Chemical Structure

Deglycobleomycin Chemical Structure

CAS No. : 78314-57-5

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Deglycobleomycin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Deglycobleomycin is an RNA cleavage agent targeting r(CUG) repeat sequences. Deglycobleomycin can selectively cleave r(CUG)exp after binding to a small molecule that recognizes r(CUG)exp. The DNA cleavage efficiency of deglycobleomycin is much lower than that of Bleomycin A5 (Pingyangmycin) (HY-N10470). However, deglycobleomycin has enhanced selective cleavage activity against r(CUG)exp. Deglycobleomycin can be used to study diseases related to r(CUG)exp expansion (such as myotonic dystrophy type 1); and for the development of drugs that precisely target and cleave pathogenic RNA[1].

分子量

1058.20

Formula

C42H63N19O10S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Deglycobleomycin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

Deglycobleomycin78314-57-5DNA/RNA SynthesisInhibitorinhibitorinhibit

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