1. Gene
  2. SLC17A4 - solute carrier family 17 member 4 Gene

SLC17A4 - solute carrier family 17 member 4 Gene

中文名称:溶质载体家族 17 成员 4

种属: Homo sapiens

同用名: KAIA2138

基因 ID: 10050 | 基因类型: protein coding

关于 SLC17A4

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:25,754,699-25,781,199 (from NCBI)

This gene has 3 transcripts (splice variants), 400 orthologues and 12 paralogues. Biased expression in small intestine (RPKM 10.3), duodenum (RPKM 9.0) and 5 other tissues.


通过调节磷酸盐的摄入量、肠道吸收、骨沉积和吸收以及肾脏排泄来维持磷酸盐稳态。控制肾脏排泄磷酸盐的中心分子是钠/磷酸盐协同转运蛋白 NPT1 (SLC17A1;MIM 182308) ,它位于肾近端小管。 NPT1 利用钠的跨膜电化学势梯度将磷酸盐转运穿过细胞膜。 SLC17A4 是肠粘膜中类似的钠/磷酸盐协同转运蛋白,在肠道吸收磷酸盐方面起着重要作用 (Shibui 等人总结,1999 [PubMed 10319585]) 。[OMIM 提供,2011 年 2 月]

Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary by Shibui et al., 1999 [PubMed 10319585]).[supplied by OMIM, Feb 2011]

SLC17A4 基因产物(2)

mRNA Protein Name
NM_001286121.1 NP_001273050.1 probable small intestine urate exporter isoform b
NM_005495.3 NP_005486.1 probable small intestine urate exporter isoform a

SLC17A4 蛋白结构


MFS_1: Major Facilitator Superfamily (45 - 444)

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  • 497 a.a.
蛋白主名 其他名称

probable small intestine urate exporter

Na/PO4 cotransporter


种属 基因名 来源 基因 ID
Mus musculus SLC17A4 MGD MGI:2442850
Felis catus SLC17A4 VGNC VGNC:65220
Bos taurus SLC17A4 VGNC VGNC:34699
Rattus norvegicus SLC17A4 RGD RGD:1584758
Canis familiaris SLC17A4 VGNC VGNC:59140
Macaca mulatta SLC17A4 VGNC VGNC:77404