TUNAR - TCL1 upstream neural differentiation-associated RNA Gene

中文名称：TCL1 上游神经分化相关 RNA

种属: Homo sapiens

同用名: BNLN; TUNA; HI-LNC78; LINC00617

基因 ID: 100507043 | 基因类型: ncRNA

关于 TUNAR

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:95,876,392-95,925,571 (from NCBI)

This gene has 5 transcripts (splice variants) and 15 orthologues. Biased expression in endometrium (RPKM 5.7), brain (RPKM 3.3) and 3 other tissues.

功能概要

该基因产生一种剪接的长链非编码 RNA，可能在维持胚胎干细胞的多能性和神经分化方面发挥作用。已发现这种 lncRNA 在亨廷顿病患者大脑尾状核中的表达随着疾病的进展而减少。也有人提出，该转录本可能在乳腺癌的进展中发挥作用。已经鉴定出可变剪接的转录物变体。[RefSeq 提供，2015 年 8 月]

This gene produces a spliced long non-coding RNA that may play a role in maintaining pluripotency and the neural differentiation of embryonic stem cells. Expression of this lncRNA in the caudate nucleus of brains from Huntington's Disease patients has been found to decrease as the disease progresses. It has also been suggested that this transcript may play a role in the progression of breast Cancer. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Aug 2015]

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATPase binding	IPI IPI: 通过物理相互作用推断	34513312	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in endoplasmic reticulum calcium ion homeostasis	IDA IDA: 通过直接分析推断	34513312	GOA
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IDA IDA: 通过直接分析推断	34513312	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	34513312	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

关联疾病

疾病名称

别名

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Glioma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

直系同源

种属	基因名	来源	基因 ID
Mus musculus	TUNAR	MGD	MGI:1917202

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