CDH8 - cadherin 8 Gene

中文名称：钙粘素 8

种属: Homo sapiens

同用名: Nbla04261

关于 CDH8

功能概要

该基因编码来自钙粘蛋白超家族的 II 型经典钙粘蛋白，即介导钙依赖性细胞粘附的整合膜蛋白。成熟的钙粘蛋白由一个大的 N 末端胞外结构域、一个单一的跨膜结构域和一个小的、高度保守的 C 末端胞质结构域组成。细胞外结构域由 5 个子结构域组成，每个子结构域包含一个钙粘蛋白基序，并且似乎决定了该蛋白质的嗜同细胞粘附活性的特异性。 II 型 (非典型) 钙粘蛋白是根据它们缺乏 I 型钙粘蛋白特有的 HAV 细胞粘附识别序列来定义的。这种特殊的钙粘蛋白在大脑中表达，并被推定参与突触粘附、轴突生长和引导。[RefSeq 提供，2008 年 7 月]

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) Cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I Cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008]