IL18BP - interleukin 18 binding protein Gene

中文名称：白细胞介素 18 结合蛋白

种属: Homo sapiens

同用名: FVH; IL18BPa

基因 ID: 10068 | 基因类型: protein coding

关于 IL18BP

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:71,998,909-72,008,200 (from NCBI)

This gene has 18 transcripts (splice variants), 89 orthologues and is associated with 1 phenotype. Broad expression in spleen (RPKM 11.4), appendix (RPKM 6.6) and 24 other tissues.

功能概要

由该基因编码的蛋白质起着促炎细胞因子 IL18 抑制剂的作用。它结合 IL18，阻止 IL18 与其受体结合，从而抑制 IL18 诱导的 IFN-γ 产生，从而导致 1 型 T 辅助细胞免疫反应降低。该蛋白质在单核细胞中组成型表达和分泌。在克罗恩病患者的肠道组织中检测到这种蛋白质水平升高。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2011 年 2 月]

The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

IL18BP 基因产物(7)

mRNA	Protein	Name
NM_001039659.2	NP_001034748.1	interleukin-18-binding protein isoform a precursor
NM_001039660.2	NP_001034749.1	interleukin-18-binding protein isoform a precursor
NM_001145055.1	NP_001138527.1	interleukin-18-binding protein isoform b precursor
NM_001145057.1	NP_001138529.1	interleukin-18-binding protein isoform a precursor
NM_005699.3	NP_005690.2	interleukin-18-binding protein isoform c precursor
NM_173042.2	NP_766630.2	interleukin-18-binding protein isoform a precursor
NM_173044.3	NP_766632.2	interleukin-18-binding protein isoform d precursor

蛋白主名

其他名称

interleukin-18-binding protein

MC51L-53L-54L homolog gene product

重组 IL18BP 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7211	IL-18BP Protein, Human (CHO)	O95998-2 (T31-G194)	≥95%
HY-P72575	IL-18BP Protein, Human (HEK293, hFc)	AAD17187.1 (T29-G192)	≥95%
HY-P74824	IL-18BP Protein, Human (192a.a, HEK293, hFc)	O95998 (M1-G192)	≥95%
HY-P77709	IL-18BP Protein, Human (HEK293, His)	O95998-2 (T31-G194)	≥95%
HY-P78156	IL-18BP Protein, Human (Biotinylated, HEK293, His-Avi)	O95998-2 (T31-G194)	≥95%

关联疾病

疾病名称

别名

Hepatitis, Fulminant Viral

Hepatitis, Fulminant Viral, Susceptibility To	FVH
Fulminant Viral Hepatitis	{Hepatitis, Fulminant Viral, Susceptibility To}

Molluscum Contagiosum

Water Warts

Molluscum Verrucosum

Cowpox

Yaba

Viral Hepatitis

Animal Viral Hepatitis	Hepatitis, Viral, Animal
Human Viral Hepatitis	Viral Hepatitis With Hepatic Coma

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Adult-Onset Still'S Disease

Adult-Onset Still Disease	Adult Onset Still'S Disease
Adult Still'S Disease	Still'S Disease Adult Onset
Aosd	Wissler-Fanconi Syndrome
Stills Disease Adult-Onset	Still'S Disease, Adult-Onset
Wissler'S Syndrome

Smallpox

Variola	Ordinary Smallpox
Alastrim	Amaas

Toxic Optic Neuropathy

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Hemophagocytic Lymphohistiocytosis

Lymphohistiocytosis, Hemophagocytic	Haemophagocytic Syndrome
Lymphohistiocytosis Hemophagocytic	Hemophagocytic Syndrome
Familial Hemophagocytic Lymphocytosis	Histiocytoses Of Mononuclear Phagocytes
Haemophagocytic Lymphohistiocytosis Nos

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-102019	NSC61610	Inhibitor	99.50%	否
HY-RS06709	IL18BP Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	IL18BP	MGD	MGI:1333800
Canis familiaris	IL18BP	VGNC	VGNC:41952
Rattus norvegicus	IL18BP	RGD	RGD:620042
Macaca mulatta	IL18BP	VGNC	VGNC:73713
Bos taurus	IL18BP	VGNC	VGNC:54438
Felis catus	IL18BP	VGNC	VGNC:82043
Others	IL18BP	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

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IL18BP - interleukin 18 binding protein Gene

关于 IL18BP

功能概要

IL18BP 基因产物(7)

重组 IL18BP 蛋白

关联疾病

直系同源

热门区域

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IL18BP - interleukin 18 binding protein Gene

关于 IL18BP

功能概要

IL18BP 基因产物(7)

重组 IL18BP 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z