1. Gene
  2. CDH10 - cadherin 10 Gene

CDH10 - cadherin 10 Gene

中文名称:钙粘蛋白 10

种属: Homo sapiens

基因 ID: 1008 | 基因类型: protein coding

关于 CDH10

Cytogenetic location: 5p14.2-p14.1 Genomic coordinates (GRCh38): 5:24,487,100-24,644,978 (from NCBI)

This gene has 4 transcripts (splice variants), 228 orthologues, 33 paralogues and is associated with 90 phenotypes. Biased expression in brain (RPKM 13.5) and prostate (RPKM 2.1).

功能概要

该基因编码钙粘蛋白超家族的 II 型经典钙粘蛋白。该基因的可变剪接导致多个转录变体。这些变体中至少有一个编码一种前原蛋白,该蛋白经过蛋白水解处理后生成成熟的钙粘蛋白。这些完整的膜蛋白介导钙依赖性细胞粘附,由一个大的 N 末端细胞外结构域、一个跨膜结构域和一个小的、高度保守的 C 末端胞质结构域组成。细胞外结构域由 5 个子结构域组成,每个子结构域包含一个钙粘蛋白基序,并且似乎决定了该蛋白质的嗜同细胞粘附活性的特异性。 II 型 (非典型) 钙粘蛋白是根据它们缺乏 I 型钙粘蛋白特有的组氨酸-丙氨酸-缬氨酸 (HAV) 细胞粘附识别序列来定义的。这种特殊的钙粘蛋白主要在大脑中表达,并被推定参与突触粘连、轴突生长和引导。该基因的突变可能与人类患者的肺鳞状细胞癌和结直肠癌有关。[RefSeq 提供,2015 年 11 月]

This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) Cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I Cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal Cancer in human patients. [provided by RefSeq, Nov 2015]

CDH10 基因产物(4)

mRNA Protein Name
NM_001317222.2 NP_001304151.1 cadherin-10 isoform 2
NM_001317224.2 NP_001304153.1 cadherin-10 isoform 3 preproprotein
NM_001362460.1 NP_001349389.1 cadherin-10 isoform 4 preproprotein
NM_006727.5 NP_006718.2 cadherin-10 isoform 1 preproprotein

CDH10 蛋白结构

Cadherin

Cadherin: Cadherin domain (72 - 150)

Cadherin

Cadherin: Cadherin domain (165 - 259)

Cadherin

Cadherin: Cadherin domain (275 - 358)

Cadherin

Cadherin: Cadherin domain (389 - 477)

Cadherin

Cadherin: Cadherin domain (494 - 587)

Cadherin_C

Cadherin_C: Cadherin cytoplasmic region (637 - 781)

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  • 600
  • 788 a.a.
蛋白主名 其他名称

cadherin-10

T2-cadherin

重组 CDH10 蛋白

目录号 产品名 蛋白编号 纯度
HY-P78769 Cadherin-10/CDH10 Protein, Human (HEK293, His) Q9Y6N8 (G55-A613) ≥95%
HY-P79241 Cadherin-10/CAD-10 Protein, Human (CHO, hFc) Q9Y6N8 (E23-A613) ≥95%

关联疾病

疾病名称 别名
Lung Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lung

Squamous Cell Lung Carcinoma

Epidermoid Cell Carcinoma Of The Lung

Squamous Cell Lung Cancer

Craniofacial-Deafness-Hand Syndrome

CDHS

Craniofacial Deafness Hand Syndrome

Sommer-Young-Wee-Frye Syndrome

Features Of Flat Facial Profile, Hypertelorism, Hypoplastic Nose With Slitlike Nares, And A Sensorineural Hearing Loss

Craniofacial-Hearing Loss-Hand Syndrome

Childhood Disintegrative Disease

Childhood Disintegrative Disorder

Disintegrative Psychosis

Heller'S Syndrome

Symbiotic Psychosis

Dementia Infantilis

Heller Syndrome

Shared Paranoid Disorder

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

Cri-Du-Chat Syndrome

5p Deletion Syndrome

5p Partial Monosomy Syndrome

Monosomy 5p

Cat Cry Syndrome

Chromosome 5p Deletion Syndrome

Cri Du Chat Syndrome

5p- Syndrome

5p Minus Syndrome

Chromosome 5p- Syndrome

Chromosome 5 Short Arm Deletion Syndrome

Chromosome 5p Deletion

Deletion 5p

Cri Du Chat

5p Partial Deletion Syndrome

Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CDH10 VGNC VGNC:70804
Felis catus CDH10 VGNC VGNC:102179
Bos taurus CDH10 VGNC VGNC:27091
Rattus norvegicus CDH10 RGD RGD:619741
Canis familiaris CDH10 VGNC VGNC:39019
Mus musculus CDH10 MGD MGI:107436
Others CDH10 NCBI