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  2. TSPAN3 - tetraspanin 3 Gene

TSPAN3 - tetraspanin 3 Gene

中文名称:四跨膜蛋白 3

种属: Homo sapiens

同用名: TM4-A; TM4SF8; TSPAN-3

基因 ID: 10099 | 基因类型: protein coding

关于 TSPAN3

Cytogenetic location: 15q24.3 Genomic coordinates (GRCh38): 15:77,041,404-77,071,109 (from NCBI)

This gene has 10 transcripts (splice variants), 285 orthologues and 32 paralogues. Ubiquitous expression in fat (RPKM 113.6), colon (RPKM 109.2) and 25 other tissues.

功能概要

由该基因编码的蛋白质是跨膜 4 超家族的成员,也称为四跨膜蛋白家族。这些成员中的大多数是细胞表面蛋白,其特征在于存在四个疏水结构域。这些蛋白质介导在细胞发育、活化、生长和运动的调节中起作用的信号转导事件。已发现该基因使用替代聚腺苷酸化位点。已经描述了编码不同亚型的多个替代转录本。[RefSeq 提供,2009 年 12 月]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Multiple alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Dec 2009]

TSPAN3 基因产物(3)

mRNA Protein Name
NM_001168412.2 NP_001161884.1 tetraspanin-3 isoform 3
NM_005724.6 NP_005715.1 tetraspanin-3 isoform 1
NM_198902.3 NP_944492.1 tetraspanin-3 isoform 2

TSPAN3 蛋白结构

Tetraspannin

Tetraspannin: Tetraspanin family (9 - 237)

  • 0
  • 100
  • 200
  • 253 a.a.
蛋白主名 其他名称

tetraspanin-3

tetraspan 3

关联疾病

疾病名称 别名
Stormorken Syndrome

Thrombocytopathy, Asplenia, And Miosis

Stormorken-Sjaastad-Langslet Syndrome

STRMK

York Platelet Syndrome

Yps

Thrombocytopathy, Asplenia And Miosis

Thrombocytopathy Asplenia Miosis

Thrombocytopathy-Asplenia-Miosis Syndrome

Miosis Disorder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TSPAN3 VGNC VGNC:47919
Bos taurus TSPAN3 VGNC VGNC:36436
Mus musculus TSPAN3 MGD MGI:1928098
Rattus norvegicus TSPAN3 RGD RGD:1359444
Macaca mulatta TSPAN3 VGNC VGNC:79085
Macaca fascicularis TSPAN3 NCBI
Susscrofa domestica TSPAN3 NCBI
Others TSPAN3 NCBI